胎盘型谷胱甘肽S转移酶mRNA在大鼠肝癌癌前病变组织中的原位表达  

Expression of glutathione S tranferase placental mRNA in hepatic preneoplastic lesions in rats

作　　者：朱焕章[1] 张新立[1] 陈意生[1] 

机构地区：[1]第三军医大学基础部病理学教研室

出　　处：《第三军医大学学报》1996年第6期502-504,共3页Journal of Third Military Medical University

基　　金：国家自然科学基金

摘　　要：应用原位杂交技术，观察了二乙基亚硝胺（ＤＥＮ）诱发大鼠肝癌前病变组织中胎盘型谷胱甘肽Ｓ转移酶（ＧＳＴ－Ｐ）ｍＲＮＡ的表达。结果显示，ＧＳＴ－ＰｍＲＮＡ主要在癌前病变肝组织中的变异灶及灶外卵圆形细胞内表达，且在变异灶间或和同一灶内阳性细胞间表达程度不尽一致，而正常肝、再生肝组织中未见其表达。The expression of glutathione S transferase placental (GST P) mRNA was observed in hepatic preneoplastic lesions induced with diethylnitrosamine (DEN) with in situ hybridization in rats. It was found that GST P mRNA mainly expressed in altered foci and some of oval cells in hepatic preneoplastic lesions and the extent of its expression was different among foci or/and positive cells in the same foci whereas no expression was observed in normal and regenerating hepatic tissue. Our findings indicate that cells in altered foci and oval cells may be preneoplastic cells in the experimental hepatocellular carcinoma at the molecular level.

关 键 词：肝肿瘤 谷胱甘肽转移酶 MRNA 

分 类 号：R735.702[医药卫生—肿瘤]