血管紧张素Ⅱ受体-1基因多态性与脑血管病的关系  

Relationship between the angiotensin Ⅱ type 1 receptor gene polymorphisms and cerebrovascular disease

作　　者：和姬苓[1] 王永福[2] 杨国安[2] 王小利[3] 孙洪英[4] 杨巧莲[1] 侯兴旺[1] 刘波[1] 陈鹏[2] 王宏坤[2] 

机构地区：[1]包头医学院第一附属医院神经内科,包头014010 [2]包头医学院第一附属医院基因诊断中心,包头014010 [3]包头医学院第一附属医院神经外科,包头014010 [4]包头医学院

出　　处：《临床神经病学杂志》2007年第1期12-14,共3页Journal of Clinical Neurology

基　　金：包头市医药卫生基金项目(2003G2136-27)

摘　　要：目的探讨血管紧张素Ⅱ受体-1(AT1R)基因多态性与脑血管病(CVD)的关系。方法采用聚合酶链式-限制性片段长度多态性方法,检测104例CVD患者(CVD组)及98名健康人(正常对照组)的AT1R基因多态性,并进行分析。结果在研究总对象中没有发现CC基因型。CVD组AA、AC基因型频率分别为40.4%、59.6%,A、C等位基因频率分别为70.1%、29.9%;正常对照组AA、AC基因型频率分别为91.8%、8.1%,A、C等位基因频率分别为95.9%、4.1%。AT1R各基因型和等位基因频率在CVD组和正常对照组分布差异有显著性(均P<0.05)。结论AT1R基因多态性可能与CVD发病有关。Objective To explore the relationship between angiotensin Ⅱtype 1 receptor （AT1R） gene polymorphisms and cerebrovascular disease （CVD）. Methods The 104 patients with CVD and 98 healthy individuals were detected the AT1R genotypes polymorphisms by restriction fragment length polymorphism in order to analysis. Results CC genotype was not found both in CVD and control group. In CVD group, genotypic frequency of AA was 40.4% and AC was 59.6%. The allele frequency of A was 70. 1% and C was 29. 9%. In control group, genotypic frequency of AA was 91.8% and AC was 8.1%. The allele frequency of A was 95.9% and C was 4. 1%. AT1R polymorphism revealed there was significant difference between the genotype and allelic distribution in CVD patients and those of in controls （ all P 〈 0. 01 ）. Conclusion The polymorphism of AT1R is related to the incidence of cerebrovascular disease.

关 键 词：血管紧张素Ⅱ受体-1 基因多态性 脑血管病 

分 类 号：R743.3[医药卫生—神经病学与精神病学]