尼莫地平对Alzheimer病患者认知功能和听觉事件相关电位P300的影响  

Effects of Nimodipine on cognitive,auditory event-related potentials P300 in patients with Alzheimer disease

作　　者：陈玉娟[1] 刘学源[1] 齐小忠[1] 边伟红[1] 贾怡蓓[1] 

机构地区：[1]上海市第十人民医院神经科,200072

出　　处：《临床神经病学杂志》2007年第1期29-31,共3页Journal of Clinical Neurology

摘　　要：目的观察尼莫地平对Alzheimer病(AD)患者认知功能和听觉事件相关电位P300的影响。方法将65例AD患者随机分成两组,尼莫地平治疗组(尼莫地平组,32例):尼莫地平注射液治疗;吡拉西坦对照组(吡拉西坦组,33例):吡拉西坦注射液治疗。应用简易精神状态检查量表(MMSE)评定两组患者治疗前后认知功能状况,并进行治疗前后P300检查。同时记录药物不良反应。结果两组各30例进入结果分析。治疗前两组MMSE评分、P300的潜伏期及波幅差异无显著性(均P>0.05)。治疗14d、30d时,两组MMSE评分显著提高(均P<0.01),P300潜伏期均有缩短,波幅均有提高(尼莫地平组P<0.01,吡拉西坦组P<0.05);治疗90d时,尼莫地平组MMSE评分显著提高、P300潜伏期显著缩短、波幅显著提高(均P<0.01)。治疗后14d时认知功能改善尼莫地平组明显优于吡拉西坦组(总有效率分别为76.67%,70%)(P<0.05)。两组治疗期间无严重不良反应。结论尼莫地平注射液能够改善AD患者的认知功能,比吡拉西坦更有效;这可能与尼莫地平的脑保护作用有关。Objective To observe the effects of Nimodipine on cognitive and auditory event-related potentials P300 in patients with Alzheimer disease （ AD ）. Methods 65 patients with AD were randomly divided into two groups：Nimodipine group （ n=32 ）, treated with Nimedipine injection; Piracetam group （ n=33 ）, treated with Piracetam injection. Cognitive function and the amelioration of intelligence were assessed with mini mental state examination （ MMSE）, and P300 was detected before and after treatment. The side effects of the drugs were recorded at the same time. Results 30 cases in both groups were involved in the analysis of results. There were no significant differences in the scores of MMSE, P300 latencies and amplitudes from target before treatment between the two groups （ all P 〉 0. 05 ）. The scores of MMSE increased significantly（ all P 〈 0. 01 ） , P300 latencies reduced and amplitudes increased significantly（ Nimedipine group P 〈0. 01, Piracetam group P 〈0. 05 ） in both two groups 14 d and 30 d after treatment. The score of MMSE increased significantly, P300 latencies reduced and amplitudes increased significantly （ all p 〈0. 01 ） only in the Nimedipine group 90 d after treatment. The intellectual amelioration was significant in the Nimodipine group than that of in the Piracetam group （76. 67% ,70% ）（ P 〈0.05）. No obvious adverse reaction was observed during treatment in both groups. Conclusions Nimodipine can improve the cognitive function in patients with AD, the effect of Nimedipine was better than that of Piracetam. It maybe relate to cerebral protective effects of Nimodipine.

关 键 词：尼莫地平 ALZHEIMER病 认知功能 P300 吡拉西坦 

分 类 号：R749.16[医药卫生—神经病学与精神病学]