尼莫地平对高血压脑出血患者脑血管动力学指标的影响  

Effects of Nimodipine on patients with hypertensive cerebral hemorrhage by measuring the cerebral vascular hemodynamics indexes

作　　者：张一凡[1] 袁州[2] 张忠雷[1] 

机构地区：[1]上海市松江区中心医院神经内科,201600 [2]上海市中医药大学附属曙光医院松江方塔分院内科

出　　处：《临床神经病学杂志》2007年第1期61-63,共3页Journal of Clinical Neurology

基　　金：上海市医学发展基金资助课题(95Ⅱ015)

摘　　要：目的观察尼莫地平对高血压脑出血(HCH)患者的脑血管动力学参数(CVHI)的影响,探讨尼莫地平治疗HCH的疗效和作用机制。方法将96例HCH患者随机分成尼莫地平治疗组(57例)和常规治疗组(39例)。分别对两组患者治疗前后CVHI进行检测,比较治疗前后的血肿量和水肿面积,评估两组疗效。结果尼莫地平组用药后的平均血流量(Qmean)值较常规治疗组有明显的升高(P<0.05),外周血管阻力(R)和临界压力(CP)值明显低于常规治疗组(P<0.05、P<0.01),两组平均血流速(Vmean)差异无显著性;尼莫地平组治疗后的血肿量和水肿面积积分差较常规治疗组的差异不显著;尼莫地平组的好转率(85.97%)较常规治疗组(58.98%)显著提高(P<0.01)。结论尼莫地平治疗HCH具有增加脑血流量、降低脑血管阻力、提高近期疗效的作用。Objective To study the effects and mechanism of Nimodipine on patients with hypertensive cerebral hemorrhage （HCH） by measuring the cerebral vascular hemodynamics indexes（CVHI）. Methods 96 patients with HCH were randomly divided into the Nimodipine therapeutic group （57 cases） and the control group （39 cases）. All patients were given conventional treatments, while Nimodipine was given to the Nimodipine therapeutic group. The CVHI parameters were measured in the two groups before and after treatment. Volume of hematoma and area of edema were measured by CT scan. Therapeutic effects were assessed by physician respectively. Results In contrast with the control group, Qmean increased significantly in the Nimodipine therapeutic group after treatment （P 〈 0. 05）, R and CP decreased significantly after treatment （ P 〈 0. 05 and P 〈 0. 01 respectively ） while Vmean remained unchanged;there were no differences in the volume of hematoma and the area of edema between two groups; therapeutic effect rat was obviously better in Nimodipine therapeutic group （ 85.97% ） than that of control group （58.98%） （P 〈 0. 01 ）. Conclusions Nimodipine can increases cerebral blood flow, decreases cerebral vascular resistence and improves short-term therapeutic outcome.

关 键 词：脑血管动力学参数 尼莫地平 脑出血 

分 类 号：R743.3[医药卫生—神经病学与精神病学]