不同术式大鼠原位肝移植模型的比较  

Comparative study on model of orthotopic liver transplantation with different ways in rats

作　　者：吴建武[1] 胡明政[1] 杨小华[1] 秦磊[1] 钱海鑫[1] 

机构地区：[1]苏州大学第一附属医院普外科,江苏苏州215006

出　　处：《肝胆胰外科杂志》2007年第1期18-19,21,共3页Journal of Hepatopancreatobiliary Surgery

摘　　要：目的比较二种不同术式大鼠原位肝移植模型的优劣,建立一种稳定的大鼠肝移植模型。方法采用二袖套法完成大鼠原位肝移植40例,采用三袖套法施行大鼠原位肝移植20例。结果二袖套法手术成功率为92.5%(37/40),1周存活率为89.2%(33/37)。三袖套法手术成功率为85%(17/20),1周存活率为11.8%(2/17)。结论大鼠原位肝移植二袖套法较三袖套法远期存活率高,并发症少,是一种稳定可靠的大鼠肝移植模型。Objective To compare the excellence and disadvantage of the model orthotopic liver transplantation （OLT） with two kinds of different ways of operation in rats and to establish a steady method of orthotopic fiver transplantation in rats. Methods OLT was performed on 40 rats using the modified ＂two-cuff method＂ and 20 rats using the modified ＂three-cuff method＂. Results The successful rate of operation and 1-week survival rate were 92.5% and 89.2% for modified ＂two-cuff method＂, meanwhile 85% and 10% for the modified ＂three-cuff method＂, respectively. Conclusion The logn-term survival rate of modified ＂two-cuff method＂ is higher than that of modified ＂three-cuff method＂, the complication of the modified ＂two-cuff method＂ is fewer. It is a reliable and steady operation for orthotopic liver transplantation in rats.

关 键 词：大鼠 肝移植 模型 动物 

分 类 号：R-332[医药卫生]