短暂性脑缺血发作的质子磁共振波谱研究  

Study of ~1H MR Spectroscopy in Transient Ischemic Attacks

作　　者：卢洁[1] 李坤成[1] 张苗[1] 王默力[2] 宋宏杰[2] 王志群[1] 

机构地区：[1]首都医科大学宣武医院医学影像学部放射科,北京100053 [2]首都医科大学宣武医院神经内科,北京100053

出　　处：《放射学实践》2007年第2期136-139,共4页Radiologic Practice

基　　金：北京市优秀人才培养资助项目(20042D0501809)

摘　　要：目的探讨短暂性脑缺血发作(TIA)的质子磁共振波谱(1H-MRS)改变及其临床应用价值。方法分别对25例TIA患者和25例健康志愿者(正常对照组)行1H-MRS,测量两侧大脑半球半卵圆中心代谢物包括氮-乙酰天门冬氨酸(NAA)、胆碱(Cho)和肌酸(Cr)的波峰下面积,计算NAA/Cho、NAA/Cr和Cho/Cr。对TIA患者病变侧与对侧正常脑组织及正常对照组之间各代谢物比值的差异进行统计学分析。结果TIA患者病变侧半卵圆中心的NAA/Cho(1.48±0.23)、NAA/Cr(1.23±0.17)低于对侧(1.68±0.24,1.79±0.21)及正常对照组(1.66±0.24,1.78±0.17),差异有极显著性意义(P<0.01);其Cho/Cr(1.18±0.19)高于对侧(1.05±0.16)及正常对照组(1.04±0.12),差异有显著性意义(P<0.05)。结论1H-MRS能够早期发现TIA患者的脑代谢异常,对临床诊断和治疗具有重要价值。Objective：Using ^1H magnetic resonance spectroscopy imaging （^1H-MRSI） to investigate the cerebral metabolic changes in patients with transient ischemic attack （TIA）. Methods：^1H MRS were performed in 25 patients with TIA and 25 control subjects. Cerebral metabolism was studied by assessing the ratios of nitro-acetyl aspartate to choline （NAA/ Cho） as well as to creatine （NAA/Cr） ,and the ratio of choline to creatine （Cho/Cr） from non-affected regions in the centrum semiovale of both hemispheres. Results： In TIA patients, the NAA/Cho and NAA/Cr of the affected area （1.48±0. 23,1.23±0.17, respectively） were significantly decreased and lower than that of non-affected hemisphere （1.68±0.24, 1.79±0.21 ,respectively） as well as the control subjects （1.66±0. 24,1. 78±0. 17, respectively） with significant statistic difference （P〈0.01）. The Cho/Cr of the affected hemisphere （1.18±0. 19） was significantly increased and higher than that of the non-affected hemisphere （1.05±0.16） and control subjects （1.04±0.12） ,with statistic difference（P〈0.05）. Conclusion：Abnormal cerebral metabolic changes in patients with TIA could be demonstrated by ^1H-MRSI.

关 键 词：磁共振成像 磁共振波谱学 脑缺血 短暂性 

分 类 号：R743.3[医药卫生—神经病学与精神病学]