晚期骨转移前列腺癌63例诊治分析  

Clinical Analysis of Prostate Cancer with Bone Metastasis:A Report of 63 Cases

作　　者：沈志坚[1] 谢红林[1] 汪超军[1] 蔡松良[1] 谢立平[1] 汪朔[1] 张志根[1] 

机构地区：[1]浙江大学医学院附属第一医院泌尿外科,杭州市310003

出　　处：《中国肿瘤临床》2007年第3期162-164,共3页Chinese Journal of Clinical Oncology

摘　　要：目的:总结晚期骨转移前列腺癌诊治经验。方法:63例前列腺癌骨转移患者行姑息性前列腺切除或内分泌治疗,其中1例辅助治疗后行根治手术。结果:52例(82.5%)随访6～72个月,平均30个月。15例治疗后12～48个月(平均21个月)转移死亡;1例因脑血管意外治疗6个月后死亡。生存36例中,随访至少1年(平均34个月),均无症状生存。内分泌治疗6个月PSA反应率达100%。结论:前列腺癌骨转移患者行内分泌治疗早期效果明确,对梗阻症状明显者加姑息性前列腺切除能提高生活质量。Objective： To summarize the diagnosis and treatment of 63 cases of advanced stage prostate cancer with osseous metastasis. Methods： Palliative prostatectomy or endocrine therapy was performed for the 63 cases with osseous metastasis of prostate cancer, among which 1 received radical prostatectomy after neoadjuvant therapy. Results： Fifty-two cases were followed up for 6 to 72 months （averaging 30 months）. During that time, 15 patients died of metastasis of the prostate cancer within 12 to 48 months （averaging 21 months） after treatment and 1 patient died of cerebrovascular accident 6 months after treatment. The other 36 surviving cases received follow up for a minimum of 12 months （averaging 34 months）, and all survived asymptomatically. The PSA response rate reached 100% 6 months after treatment. Conclusions： The early curative effect of endocrine therapy for cases with osseous metastasis of prostate cancer is obvious, and palliative prostatectomy can improve the quality of life for the patients with symptoms of obstruction.

关 键 词：前列腺肿瘤 骨转移 激素治疗 疗效 

分 类 号：R737.25[医药卫生—肿瘤]