颈动脉粥样硬化与缺血性卒中亚型的相关性研究  

Carolid Atherosclerosis and lschemic Stroke Subtypes

作　　者：顾海波[1] 洪小苏[2] 陈建昌[2] 高岚[2] 焦阳[2] 

机构地区：[1]上海交通大学附属第一人民医院急诊内科,200080 [2]苏州大学附属第二医院心血管内科,215004

出　　处：《国际脑血管病杂志》2007年第1期25-28,共4页International Journal of Cerebrovascular Diseases

摘　　要：目的：探讨颈动脉粥样硬化与缺血性卒中亚型的相关性。方法：448例缺血性卒中患者按TOAST分型法分类：动脉粥样硬化血栓形成性脑梗死组（AI，n=143）、腔隙性梗死组（LI，n=225）、心源性栓塞性梗死组（Cl,n=30）和病因不明性卒中组（50例）。另选90例健康体检者作为对照组。采用多普勒超声检测颈动脉内膜中膜厚度（IMT）和斑块积分（Ps）。结果：AI和LI亚组颈动脉IMT和PS显著高于对照组（P〈0．05）。AI亚组Ps的ROC曲线下面积远大于IMT（0．78比0．63，P〈0．05）。结论：颈动脉IMT和PS能较好地预测AI和LI的发生风险，但PS可能更可靠；颈动脉粥样硬化程度预测AI的发生风险更有效。Objectives： To explore the correlation between carotid atheroselerosis and ischemic stroke subtypes. Methods： Four hundred forty-eight patients were classified into atherothrombotic infarction （AI, n = 143）, lacunar infarction （LI, n =225）, cardioembolic infarction （CI, n =30）, and cryptogenic stroke （CS, n = 50） groups according to the Trial of Org 10172 in Acute Stroke Treatment （TOAST） classifications. Another 90 healthy subjects were selected as control group. Carotid intimal-medial thickness （IMD and plaque scores （PS） were measured by Doppler ultrasound examination. Results： Both carotid IMT and PS in the AI and LI groups were significantly higher than those in the control group （P 〈0. 05）. Receiver operating characteristic （ROC） curve in the AI and LI groups was much higher than that in the control group （0. 78 vs 0. 63, P 〈 0. 05）. Condosions： Although carotid IMT and PS can better predict the risks of AI and LI, PS may be mare effective. Carotid atheroselerosis may be used to predict the risks of AI and LI, but it is more effective to reduce AI .

关 键 词：颈动脉疾病 动脉粥样硬化 缺血性卒中 超声检查 

分 类 号：R74[医药卫生—神经病学与精神病学]