羧甲基-β-环糊精用于毛细管电泳中的手性分离  

Capillary Electrophoretic Enantiomeric Separations with 2, 6-Di-O-Carboxymethyl-β-Cyclodextrin

作　　者：靳慧[1] 李方[1] 顾峻岭[1] 傅若农[1] 刘玉[1] 戴荣继[1] 

机构地区：[1]北京理工大学化工与材料学院,北京100081

出　　处：《分析化学》1996年第12期1387-1390,共4页Chinese Journal of Analytical Chemistry

基　　金：国家自然科学基金

摘　　要：本文将水溶性良好的凌甲基-β-CD（CM-β-CD）用于分离氯霉素中间体（CPM），考察了CM-β-CD作为毛细管电泳手性选择剂的分离性能。同时研究了pH值、CM-β-PCD浓度以及甲醇对分离的影响，并比较了CM-β-CD与β-CD分离CPM时的作用机理。The water soluble 2, 6-di-O-carboxymethyl-β-cyclodextr (CM-β-CD) was used as a chiral selector to separate chloramphenicol metabolite. The effects of pH and CM-β-CD concentration on the enantiomeric separation were investigated. The addition of an organic modifier(methanol) to the buffer led to deterioration of the enantiomeric separation. The results indicated that CM-β-CD was superior to β-CD for the separation of chloramphenicol metabolite and the interaction mechanisms of CM-β-CD and β-CD were compared.

关 键 词：毛细管电泳 手性分离 羧甲基 Β-环糊精 

分 类 号：O658.9[理学—分析化学]