β-catenin和Ki-67在人宫颈癌组织中的表达及其意义  

The Expression and Clinical Significances of β-catenin and Ki67 in Human Cervical Carcinoma

作　　者：李东辉[1] 李明众[1] 张薛榜[1] 

机构地区：[1]陕西省人民医院老年肿瘤病区,710068

出　　处：《实用癌症杂志》2007年第1期28-30,46,共4页The Practical Journal of Cancer

摘　　要：目的探讨β-catenin和Ki-67在宫颈癌发生、发展、转移中的作用及其相互关系。方法采用免疫组织化学染色的方法,检测了55例宫颈癌、12例宫颈上皮内瘤变(CIN)、11例正常组织中β-catenin和Ki-67的表达水平。结果β-catenin在正常宫颈、CIN、宫颈癌组织中的异常表达率分别为18.3%、50.0%、80.0%(P均<0.05);β-catenin异常表达与宫颈癌的病理分级、临床分期、淋巴结转移有关。Ki-67在宫颈癌组织、正常宫颈组织、CIN中的阳性表达率分别为74.5%,0,41.6%(P均<0.05);Ki-67的阳性表达与宫颈癌的临床分期、淋巴结转移有关。结论联合检测β-catenin和Ki-67,有助于判断宫颈癌分期及预后,作为临床治疗的参考指标。Objective To study the expressions and their clinical significances of β-catenin and Ki-67 in human cervical carcinoma and to elucidate their roles and correlation in lymphatic matastasis and progonosis. Methods Tissues from fifty-five cervical carcinoma,twelve CIN and eleven nomal cervices were obtained and analysed of β-catenin and Ki-67 expressions with immunohistrochemistry. Results The rate of [3-catenin abnormal expression in normal tissue,CIN ,cervical carcinoma were 18.3% , 50.0% - 80.0% （ P 〈 0.05 ）. β-catenin expression was positively correlated with pathological grade, stage of disease, lymphatic matastasis. The positive rate of Ki-67 expression were 74.5% ,0,41.6% in cervical carcinoma, normal tissue ,CIN （P 〈 0.05 ）. Ki-67 expression was positively correlated with stage of disease, lymphatic matastasis. Conclusion Combined analysis of these two proteins is helpful to judge stage and prognosis of cervical carcinoma, and can be a reference factor of the clinical theraphy.

关 键 词：Β-连环素 KI-67抗原 宫颈癌 免疫组织化学 

分 类 号：R737.33[医药卫生—肿瘤]