Two New Coumarins from Fraxinus chinensis Rexb.  

作　　者：Dong-Mei Zhang Li-Li Wang Jia Li Li-Hong Hu 

机构地区：[1]Shanghai Research Center for Modernization of Traditional Chinese Medicine, Shanghai Institute of Materia Medica, Shanghai Institute for Biological Sciences, the Chinese Academy of Sciences, Shanghai 201203, China [2]National Center for Drug Screening, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, the Chinese Academy of Sciences, Shanghai 201203, China [3]School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China

出　　处：《Journal of Integrative Plant Biology》2007年第2期218-221,共4页植物学报（英文版）

基　　金：Supported by the National Natural Science Foundation of China （30371679）.

摘　　要：The ethanol extract of the stem bark of Fraxinus chinensis Roxb. showed good inhibitory bioactivity against VEGF receptor-1 kinase （IC50：13.8 μg/mL）. In order to find new and bioactive compounds, the chemical constituents of the stem bark of F. chinensis were investigated and two new coumarins, namely 6＇-O-sinapinoyl esculin （compound 1） and 6＇-O-vanillyl esculin （compound 2）, together with eleven known compounds （compounds 3-13） were isolated. The structures of the two new compounds were identified by their physicochemical properties and spectral analysis, particularly one- and two-dimensional nuclear magnetic resonance spectral methods. The known compound, oleuropein （compound 11）, exhibited moderate activity （IC50：（8.7 ± 1.3） μmol/L） to inhibit VEGF receptor- 1 kinase.The ethanol extract of the stem bark of Fraxinus chinensis Roxb. showed good inhibitory bioactivity against VEGF receptor-1 kinase （IC50：13.8 μg/mL）. In order to find new and bioactive compounds, the chemical constituents of the stem bark of F. chinensis were investigated and two new coumarins, namely 6＇-O-sinapinoyl esculin （compound 1） and 6＇-O-vanillyl esculin （compound 2）, together with eleven known compounds （compounds 3-13） were isolated. The structures of the two new compounds were identified by their physicochemical properties and spectral analysis, particularly one- and two-dimensional nuclear magnetic resonance spectral methods. The known compound, oleuropein （compound 11）, exhibited moderate activity （IC50：（8.7 ± 1.3） μmol/L） to inhibit VEGF receptor- 1 kinase.

关 键 词：COUMARINS Fraxinus chinensis VEGF receptor-1 kinase. 

分 类 号：Q946.82[生物学—植物学]