鬼臼素衍生物Vp-16和Vm-26合成副产物之结构和机理研究  

STDUY ON THE STRUCTURES AND MECHANISMS OF BY-PRODUCTS IN THE SYNTHESIS OF ANTITUMOR ANGENTS VP-16 AND VM-26

作　　者：罗士德[1] 范多青[1] 张起凤[1] 王惠英[1] 冉立新 张光耀 

机构地区：[1]中国科学院昆明植物研究所植化开放实验室,昆明650204

出　　处：《天然产物研究与开发》1996年第4期16-19,共4页Natural Product Research and Development

摘　　要：本文报导了以4′-去甲表鬼臼素-4-β-D-葡萄糖甙分别与二甲醇缩乙醛和噻吩甲醛反应合成抗肿瘤药物依托泊甙(Vp-16)和替尼泊甙(Vm-26)中得到的两个主要副产物Vp-x和Vm-x的结构鉴定,并对其反应机理进行了探讨。In the sythesis of Anti-tumor agents Etoposide (Vp-16)and Teniposide (Vm-26) from 4'-Demethyl-podophylloxin with relevant aldehyde,two by-products (Vp-x and vm-x) were obtained in the yields about 20 percents,their structures were elucidated and their machanisms were disscussed.

关 键 词：生化药物 鬼臼素衍生物 合成 副产物 结构 机理 

分 类 号：TQ464.9[化学工程—制药化工]