Alloxan诱发糖尿病实验大鼠微量元素谱的多元分析  

Multivariate Analysis Applied to the Study of Trace Elements in Alloxan-induced Diabetic Rats

作　　者：钟广涛[1] 徐晖[1] 孔聘颜[1] 劳干诚[1] 陈上云[1] 李增禧[1] 梁业成[1] 李小梁[1] 

机构地区：[1]中山大学,广东省测试分析研究所,广州市红十字会医院,广州中医学院

出　　处：《广东微量元素科学》1996年第11期44-52,共9页Trace Elements Science

基　　金：国家自然科学基金

摘　　要：为确认Ａｌｌｏｘａｎ诱发糖尿病鼠与微量元素的关连，用多元分析研究了糖尿病鼠样品中微量元素，并引出对糖尿病的新见解。用ＩＣＰ－ＡＥＳ测定了Ａｌｌｏｘａｎ诱发糖尿病鼠和对照鼠的骨、心、肾、脾、肺、肝、血和毛中１９种微量和宏量元素（Ａｌ、Ａｓ、Ｂ、Ｂａ、Ｃｄ、Ｃｏ、Ｃｒ、Ｍｇ、Ｍｎ、Ｎｉ、Ｐｂ、Ｓｅ、Ｚｎ、Ｆｅ、Ｃｕ、Ｃａ、Ｓｒ、Ｔｉ、Ｖ），结果在糖尿病鼠与对照组的微量元素间呈现一些显著差异。多元分析找到一条共同相关链（Ｍｎ－Ｎｉ－Ｃｕ－Ｓｒ－Ｔｉ），血、发样相同，与样品种类无关，此链提供了关于机体的某些特殊信息。经非线性映射，各组映射象图显示出糖尿病和对照组的样品点分布在图上不同区域。The multivariate analysis was introduced to the study of trace elements in vitro samples of diabetic subjects to ascertain the relationship between trace elements and the Alloxan-induced diabetic rats and a new perspective in the understanding of diabetes was developed.The contents of 19 kinds of elements (Al.As.B.Ba.Cd.Co.Cr.Mg.Mn.Ni.Ph.Se.Zn.Fe.Cu.Ca.Sr.Ti.V) in organs (bone, heart, kidney, spleen, lung, liver, blood,wool ) of control and Alloxan-induced diabetic rats were determined by ICP-AES. The result indicates some signiticant difference of trace elements between diseased and control subjects.By use of multivariate analysis a common correlation chain (Mn-Ni-Cu-Sr-Ti) was found, regardless of special sample as well as in blood and hair. It seems that the chain suggests some particular information of organism. After non-linear mapping, the images of different groups show that the sample points of diabetic and control group are distributed on two different areas in a plane.

关 键 词：糖尿病 胰岛素依赖型 ALLOXAN 微量元素 

分 类 号：R587.1[医药卫生—内分泌]