转化生长因子α基因与非综合征性唇腭裂  

Transforming Growth Factor-α Gene and Nonsyndromic Cleft Lip and Palate

作　　者：马敬斋[1] 梁尚争[1] 

机构地区：[1]泸州医学院口腔医学院口腔颌面外科学教研室,四川泸州646000

出　　处：《国际口腔医学杂志》2007年第1期47-49,共3页International Journal of Stomatology

摘　　要：非综合征性唇腭裂是一种复杂得多基因多因素遗传病,众多学者从候选基因和该病的关联性及基因间、基因环境间的相互作用方面进行了大量而广泛的研究。转化生长因子α是一种多肽类生长因子,促使细胞增殖和发生转化,小鼠的腭部融合时腭盖中部的上皮组织中含量较高,同时报道认为转化生长因子α等位基因同唇腭裂有联系,被作为非综合征性唇腭裂的候选基因之一。本文就转化生长因子α基因在唇腭裂发病中的作用的研究进展作一综述。Nonsyndromic cleft lip and palate （NSCLP） is a complex, multi-gene, multi-factor genetic disorder. Many scholars take a lot of study on this disorder from the association of gene and NSCLP to gene interaction, gene-environment interaction. The transforming growth factor-α （TGF-α） gene is a polypoptidic growth factor, which promotes cell proliferation and transform, It presents high level in the epithelial tissue of the media ledge of the palatal shelves at the time of shelf fusion in mice. The association of TGF-α with NSCLP, has been proposed as a candidate gene in the etiology of NSCLP. This article reviews the recent progress of the role of TGF-α gene in NSCLP.

关 键 词：转化生长因子α基因 非综合征性唇腭裂 遗传分析 环境因素 动物模型 

分 类 号：R782.2[医药卫生—口腔医学]