caspase-7、survivin在乳腺癌中的表达及相关性研究  

Expression of caspase-7,survivin in breast neoplasm and their relationship with other biomarkers.

作　　者：胡会华[1] 周士福[1] 李青国[1] 吴玉玉[1] 高玮红[1] 

机构地区：[1]苏州大学附属第四医院普通肿瘤外科,江苏无锡214062

出　　处：《四川医学》2007年第2期135-137,共3页Sichuan Medical Journal

摘　　要：目的探讨乳腺癌中caspase-7s、urvivin的表达及ER、PR、Cerb-B2、P53、Ki-67的关系。方法免疫组织化学法检测乳腺癌石蜡标本中caspase-7s、urvivin的表达,并分析与上述标志物的关系。结果34例乳腺癌中caspase-7、sur-vivin阳性率分别为73.53%、76.47%。仅caspase-7、P53间显著相关(r=0.403,P=0.018),在P53阳性组与阴性组中cas-pase-7表达高低差异显著(P=0.001),其余指标间无相关性。结论caspase-7和survivin在乳腺癌中作用不同,均可作为靶向治疗的选择,两者与上述标志物的关系及其作用机制需进一步研究。Objective This paper is to explore expression of easpase-7, survivin in breast neoplasm and their relationships with these biomarkers. Methods Expression of caspase-7, survivin in 34 patients with breast cencer was examined by immunohistochemical staining.Their relationship with biomarkers,sueh as ER,PR,Cerb-B2,P53,Ki-67,was analyzed.Results Expression of caspase-7,sur- vivin was 73.53% ,76.47%, respectively.The correlation between expression of easpase-7 and P53 was statistically significant（ r = 0.403, P = 0.018） .Significant difference of the rate of easpase-7 expression between positive and negative P53 was seen （ P = 0.001 ）. Conclusion Caspase-7, survivin play different roles in breast neoplasm. It is necessary to study their relationship with biomarkers.

关 键 词：乳腺癌 CASPASE-7 SURVIVIN 生物学标志物 

分 类 号：R737.9[医药卫生—肿瘤]