血清透明质酸Ⅲ型前胶原Ⅳ型胶原及脯氨酸肽酶对肝组织纤维化诊断的意义  

The diagnosis value of hyaluronic acid, typeⅢprocollagen, type collagen and proline dipeptidase in liver fibrosis

作　　者：范公忍[1] 任永强[1] 崔琨[1] 姬胜杰[1] 邓涛[1] 

机构地区：[1]北京军区总医院肝病研究所,北京100700

出　　处：《临床肝胆病杂志》2007年第1期19-21,共3页Journal of Clinical Hepatology

摘　　要：探讨肝病患者血清透明质酸(HA),Ⅲ型前胶原(PCⅢ),Ⅳ型胶原(CⅣ)及脯氨酸肽酶(PLD)水平与肝纤维化程度的关系。用酶联免疫(ELISA)法及生化比色法检测225例各种肝病患者血清中HA、PCⅢ、CⅣ及PLD水平,并与肝活检病理炎症分级和纤维化分期相比较。四项指标与肝组织炎症坏死及纤维化程度均呈显著相关(P<0.05)。HA、PCⅢ及CⅣ与肝纤维化相关性高于炎症,PLD与炎症的相关性高于纤维化。血清学指标与肝组织病理病变程度一致,联合检测肝病患者血清HA、PCⅢ、CⅣ及PLD水平,既可反映肝纤维化严重程度,又能了解肝坏死情况,为临床诊断治疗提供参考。To determine the relationship between hyaluronic acid （ HA）, type Ⅲ procollagen （ PC Ⅲ ）, type - Ⅳ collagen （CⅣ） or proline dipeptidase （PLD） and degree of liver fibrosis. HA, PCⅢ, CⅣ and PLD in the serum from 225 patients with all type of liver disease were measured by ELISA and biochemistry colorimetry and analyzed their relationship with the pathological inflammation - grade and fibrosis - stage of liver biopsy tissues. There were significant correlation （ P 〈 0. 05 ） between the four indexes and the degree of inflammation, necrosis and fibrosis. The serological indexes are in accordance with the pathological degree of live tissues. It could reflect both the severe degree of hepatofibrosis and the status of hepatocellular necrosis by comeasuring HA,PC Ⅲ or CⅣ and PLD in the serum, that provides reference for clinical diagnosis and treatment.

关 键 词：透明质酸 Ⅲ型前胶原 Ⅳ型胶原 脯氨酸肽酶 肝硬化 诊断 

分 类 号：R575.2[医药卫生—消化系统]