特发性门脉高压症凝血指标分析  

Analysis of abnormalities of coagulation indexes in patients with IPH

作　　者：王莉[1] 

机构地区：[1]山东大学齐鲁医院消化内科,山东济南250012

出　　处：《临床肝胆病杂志》2007年第1期27-28,共2页Journal of Clinical Hepatology

基　　金：山东省自然科学基金资助项目Y2000C16

摘　　要：研究特发性门脉高压症(IPH)和肝硬化患者的凝血酶原时间(PT)和凝血酶原标准化比率(INR)、活化部分凝血活酶时间(APTT)和纤维蛋白原(Fib)。分析其异常的原因及在IPH发病中的作用。收集IPH患者40例、肝硬化患者41例和正常对照组18例。结果IPH患者和肝硬化患者与正常组相比均存在明显的凝血异常,有轻度D IC发生。IPH凝血异常可能是感染引起的内毒素血症激活了凝血机制所致,凝血异常可引起肝内门脉微血栓形成,与其它原因所致的肝内门脉损伤,共同导致了IPH的发生。Coagulation indexes in patients with idiopathic portal hypertension （IPH） or hepatic cirrhosis （HC） were studied. The cause of the abnormalities of coagulation indexes and its roles in development of IPH were analyzed. 40 cases with IPH, 41 cases with HC and 18 healthy controls were collected. The results showed that coagulation indexes in patients with IPH or HC were obviously different from those in control group, and mild DIC was present in patients with IPH or HC. It can be concluded that the abnormalities of coagulation indexes may be caused by infection. Microthrombosis in small or medium branches of the portal vein or damages of these veins resulted by other events may lead to IPH.

关 键 词：特发性门脉高压症 凝血异常 

分 类 号：R575.2[医药卫生—消化系统]