P53及其信号通路在肿瘤耐药分子机制中的研究进展  

Roles of P53 and its signaling pathway in tumor resistance

作　　者：杨啊晶[1] 王雪梅[2] 李电东[1] 王真[1] 

机构地区：[1]中国医学科学院中国协和医科大学医药生物技术研究所,北京100050 [2]山东省聊城市人民医院,聊城252000

出　　处：《中国新药杂志》2007年第1期7-11,共5页Chinese Journal of New Drugs

基　　金：国家自然科学基金资助项目(30300424;30572204)

摘　　要：P53在肿瘤的发生发展中占有重要地位。近来,越来越多的学者注意到p53对肿瘤细胞的耐药性也具有一定影响。现从P53自身稳定性、下游靶基因的活化及P53与其他分子/基因相互作用3个方面对其在肿瘤耐药性分子机制研究的进展进行简要阐述。As well known, roles of P53 gene have been extensive in the formation and development of tumors. Recently, it has been found that the P53 is associated with a drug resistance to tumors.This article highlights research progresses of molecular mechanism of P53 in the role of the drug resistance with respect to the homeostasis and the activation of downstream target genes of P53 as well as the interactions of P53 with other molecules/genes.

关 键 词：P53 肿瘤耐药性 化疗敏感性 

分 类 号：R730.53[医药卫生—肿瘤]