惊恐障碍患者听觉信息自动处理的事件相关电位研究  

Automatic auditory information management in panic disorder patients:an event-related potentials study

作　　者：李青栋[1] 许晶[1] 赵仑[2] 刘效巍[1] 张炳蔚[1] 

机构地区：[1]大连医科大学第一临床学院神经内科,116011 [2]江苏省语言科学与神经认知工程重点实验室

出　　处：《中华医学杂志》2007年第5期330-332,共3页National Medical Journal of China

基　　金：国家自然科学基金(30570477);大连市科技局资助项目(2005E21SF133)

摘　　要：目的探讨惊恐障碍患者听觉信息自动处理的特点。方法采用事件相关电位(ERP)成分——失匹配负波(MMN),对15例惊恐障碍患者和15名正常对照的听觉信息自动处理过程进行客观评价。结果惊恐障碍患者的 MMN 波幅在60～210 ms 潜伏期窗内明显高于正常对照组(60～110 ms:F_(1,28)=11.413,P=0.02;110～160 ms:F_(1,28)=6.639,P=0.016;160～210 ms:F_(1,28)=5.758,P=0.023),且表现出早期(60～160 ms)左侧脑区优势效应。结论惊恐障碍患者存在对听觉信息变化的过度自动加工处理,为研究 PD 的发病机制提供了新的客观证据。Objective To investigate the characteristics of automatic auditory information management in sufferers of panic disorder （PD） . Method Mismatch negativity （MMN）, as a component of event-related potentials, was recorded from 15 PD patients, 8 males and 7 females, aged 40 ± 12, and 15 sex, and aged-matched controls. Repeated measures ANOVA was used on 4 representative electrodes： T3, T4, F3, and F4. Results Compared with the normal controls, the PD patients showed significant enlargement of MMN amplitude in 60-210 ms latency windows （ 60-110 ms： F1.28 = 11. 413, P = 0.02 ; 110- 160 ms：F1.28 =6. 639,P =0. 016;160-210 ms：F1.28 =5. 758,P =0.023）, and exhibited early （60-160 ms） left encephalic region predominant effect. Conclusion PD patients may deal excessive automatic processing of the auditory information changes which may assist in offering new objective evidence to understand the etiology of PD.

关 键 词：惊恐病 诱发电位 信息处理 

分 类 号：R749.99[医药卫生—神经病学与精神病学]