血管内皮生长因子受体3和Podoplanin在人结肠癌组织中的表达  

Expression of vascular endothelial growth factor receptor-3 and Podoplanin in human colonic carcinoma

作　　者：刘宝全[1] 张雅芳[1] 宿菲[2] 马晶[1] 李雪梅[1] 杨树才[1] 

机构地区：[1]哈尔滨医科大学解剖学教研室,哈尔滨150086 [2]哈尔滨医科大学生物信息学系,哈尔滨150086

出　　处：《解剖学杂志》2007年第1期22-24,共3页Chinese Journal of Anatomy

基　　金：黑龙江省自然科学基金(D0235)

摘　　要：目的:观察血管内皮生长因子受体3(vascular endothelial growth factor receptor-3,VEGFR-3)和Podoplanin在人结肠癌组织中的表达,以探讨二者标记淋巴管的特异性。方法:选择55例人结肠癌组织标本,应用免疫组织化学法观察VEGFR-3和Podoplanin在人结肠癌组织中的表达。结果:Podoplanin主要表达于淋巴管内皮细胞上,微血管极少着色;VEGFR-3主要表达于淋巴管内皮细胞上,另外在小血管内皮也有较丰富的表达。结论:Podoplanin在淋巴管内皮细胞的表达具有较高特异性,可以用来标记淋巴管。Objective： To observe the expression of vascular endothelial growth factor receptor 3（VEGFR-3） and Podoplanin at the protein level in human colonic carcinoma, and investigate their specificity in labelling the lymphatic vessel. Methods： The expression of 55 specimens of human colonic carcinoma was investigated by SP immunohistochemistry with polyclonal antibodies against VEGFR-3 and Podoplaniru Results： Podoplanin was mainly expressed in the lymphatic endothelium but seldom in the blood vessel. VEGFR-3 was mainly expressed in the lymphatic endothelium and some in the blood vessel. Conclusion ： The expression of Podoplanin in the lymphatic endothelium is much more specific than that of VEGFR-3, and thus Podoplanin can be used to label the lymphatic vessel.

关 键 词：结肠肿瘤 血管内皮生长因子受体3 PODOPLANIN 

分 类 号：R735.35[医药卫生—肿瘤]