AMPA受体与癫痫的关系  

Relationship Between AMPA Receptor and Epilepsy

作　　者：冯冠青[1] 赵世刚[1] 刘罡[1] 

机构地区：[1]内蒙古医学院第一附属医院神经内科,呼和浩特010050

出　　处：《医学综述》2007年第3期180-182,共3页Medical Recapitulate

摘　　要：癫痫是一种常见的神经系统疾病，严重危害人类健康。α-氨基羟甲基恶唑丙酸（AMPA）受体是一种游离型兴奋性谷氨酸受体，由GluR1～GluR44个亚单位组成，GluR2亚单位对Ca^2＋不通透。由于GluR2亚单位的表达天然AMPA受体通道对Ca^2＋不通透。在AMPA受体激活时，大量Ca^2＋内流导致神经损伤。AMPA受体对于癫痫发病机制的研究和治疗均有重要作用。Epilepsy is a common disease of neurology,which seriously affects the health of human. AMPA receptor is a kind of ionotropic glutamate receptors with excitability, which is composed of four subunits （GluR1-GluR4） ,among which GluR2 is impermeable to calcium. The nature AMPA receptor is normally Ca^2＋ impermeable due to the expression of GluR2 subunit. When AMPA receptor is activated,lots of intracellular Ca^2＋ result in neurons injury. AMPA receptor has the important role in epilepsy about its pathogenesis study and therapy.

关 键 词：癫痫 AMPA受体 GluR2亚单位 钙 离子 

分 类 号：R742.1[医药卫生—神经病学与精神病学]