Annexins与肿瘤的相关研究  

Related Research of Annexins and Cancer

作　　者：谢丽[1] 陈晓燕[1] 秦雪[1] 

机构地区：[1]广西医科大学第一附属医院临床医学实验中心,南宁530021

出　　处：《医学综述》2007年第3期196-198,共3页Medical Recapitulate

基　　金：广西自然科学基金(桂科自0640107)

摘　　要：膜联蛋白(Annexins)是一类Ca2+/磷脂结合蛋白,广泛存在于细胞质膜下、储Ca2+细胞器附近以及在核内或细胞外基质中,具有高度保守的C端中心结构域和独特的N末端,参与膜形成、膜转运、细胞信号传导、分化及凋亡等多种重要的生命过程。近来多项研究表明annexins与肿瘤的发生、发展、诊断及治疗密切相关。本文就annexins共同特点及其与肿瘤的相关研究简要综述。The annexins are a family of Ca^2＋/lipid-binding proteins, which exist widely under the cytomembrane, near the organnelle storing Ca^2＋ as well as in the cell nucleus or extracellular matrlx.lt has centralis of COOH-terminal with high conservation and specific NH2-terminal, which takes part in many vital process including Membrane forming, membrane transport, cell signaling, differentiation and apoptosis. Recent study data showed that unnexins is related clesely to cancer of its genesis, development, diagnosis and therapy. This article reviews annexins of their common characters and its relationship with tumor.

关 键 词：ANNEXINS 肿瘤 细胞凋亡 

分 类 号：R730.231[医药卫生—肿瘤]