Galectin-3在甲状腺乳头状癌中的表达及意义  

Expression of galectin-3 in papillary thyroid carcinoma

作　　者：吴文君[1] 许岚[1] 刘晓[2] 朱圣炜[1] 刘国萍[1] 孙荣超[3] 杨树东[3] 

机构地区：[1]江苏省无锡市第一人民医院内分泌科,214002 [2]江苏省无锡市第一人民医院普外科,214002 [3]江苏省无锡市第一人民医院病理科,214002

出　　处：《实用医学杂志》2007年第3期346-347,共2页The Journal of Practical Medicine

基　　金：南京医科大学科技发展基金资助项目(编号:NY0585)

摘　　要：目的:比较galectin-3(Gal-3)在甲状腺乳头状癌和甲状腺良性病变中的表达差异,明确其临床意义。方法:采用免疫组化EnVision二步法检测214例甲状腺手术标本中Gal-3蛋白的表达情况。结果:甲状腺乳头状癌Gal-3蛋白表达阳性率为92.6%,显著高于结节性甲状腺肿(28.1%)、腺瘤(41.8%)及甲状腺炎(12.9%)。结论:Gal-3蛋白在甲状腺乳头状癌中的表达显著高于甲状腺良性病变,可作为甲状腺乳头状癌诊断的特异指标。Objective To investigate the expression and its clinical significance of galectin-3 in papillary thyroid carcinoma and benign thyroid diseases. Methods Two hundred and fourteen samples of resected thyroid nodules were examined by En Vision immunohistochemical technique to detect the expression of galectin-3. Results The expression rate of galectin-3 was 92.6% in papillary thyroid carcinoma, 28.1% in nodular goiter, 41.8% in adenoma and 12.9% in thyroiditis. The positive expression rate of galectin-3 in papillary thyroid carcinoma was higher than that in benign thyroid diseases. Conclusion The expression of galectin-3 in papillary thyroid carcinoma is statistically higer than that in benison thyroid diseases, being acted as one of the diagnostic markers of papillary thyroid carcinoma.

关 键 词：甲状腺肿瘤 癌 乳头状 GALECTIN-3 

分 类 号：R736.1[医药卫生—肿瘤]