2型糖尿病家系正常血糖一级亲属腰围与胰岛功能的关系  

Study on waist circumference and islet function in normoglycemic first-degree relatives of type 2 diabetes patients

作　　者：余劲明[1] 黄莹[1] 颜晓东[1] 林华[1] 

机构地区：[1]广西壮族自治区人民医院内分泌科,南宁市530021

出　　处：《广西医学》2007年第1期27-29,共3页Guangxi Medical Journal

摘　　要：目的探讨2型糖尿病家系正常血糖一级亲属不同腰围者胰岛素抵抗(IR)情况和胰岛B细胞功能状况。方法测定50例2型糖尿病家系血糖正常一级亲属及30例健康人的腰围、臀围、腰/臀比、空腹胰岛素水平,计算胰岛素抵抗指数(HOMA-IR)和胰岛B细胞功能指数(HOMA-B),分析不同腰围组之间胰岛素抵抗和胰岛B细胞功能的关系。结果一级亲属组内腰围正常组和中心性肥胖组HOMA-IR水平均明显高于对照组,随着腰围的增加,IR程度加重。而HOMA-B在各组之间差异无统计学意义。结论一级亲属人群早期以胰岛素抵抗为主,而胰岛B细胞分泌功能基本正常。腰围是影响FDR胰岛素抵抗的独立危险因素。Objective To study insulin resistance （IR） and islet function in normoglycemic first-degree relatives of type 2 diabetes mellitus （FDR）with the difference of waist circumference . Methods Waist circumference,hip circumference,waist/hip ratio and Fast insulin were measured, and then HOMA-IR ,HOMA-B were calculated in 50 persons from FDR and 30 normal controls. Results HOMA-IR was significantly higher in different waist circumference FDR subgroup than that in normal controls. But HOMA-B had no significont difference in three groups. The multiple-regression analysis showed that waist circumference was the main effective factor. With the increase of waist circumference, insulin resistance became more serious. Conclusion IR could appear early in FDR, the function of B cell is normal Waist circumference might be an independent Tisk factor. Waist circumference might be an independent risk factor.

关 键 词：2型糖尿病 胰岛素抵抗 胰岛B细胞 家系调查 

分 类 号：R589.1[医药卫生—内分泌]