青白栓抗大鼠溃疡性结肠炎的实验研究  

Experimental study of Qingbai suppository in treating ulcerative colitis in rats

作　　者：潘洋[1] 张洪娟[1] 吴屹波[1] 战晶玉[1] 

机构地区：[1]黑龙江省中医研究院消化科,黑龙江哈尔滨150036

出　　处：《中国中西医结合消化杂志》2007年第1期21-24,共4页Chinese Journal of Integrated Traditional and Western Medicine on Digestion

基　　金：黑龙江省科技厅攻关项目(GC02C124-01)

摘　　要：[目的]探讨青白栓对大鼠溃疡性结肠炎(UC)的治疗作用。[方法]采用二硝基氯苯和乙酸复合方法制备大鼠UC模型,经病理切片证实造模成功后,随机分为5组,青白栓高、中、低剂量组,模型组和柳氮磺吡啶栓组。各组大鼠根据其分组分别给予相应的处理20 d后,检测各组大鼠结肠组织中超氧化物歧化酶(SOD)、丙二醛(MDA)和血清白细胞介素2(IL-2)、白细胞介素6(IL-6)、肿瘤坏死因子α(TNF-α)I、gAI、gM、体重及肠重指数的变化。[结果]青白栓高、中剂量组动物组织中SOD显著降低,MDA显著下降(P<0.01),青白栓高剂量组动物血清中IL-2I、L-6、TNF-α均显著降低(P<0.05,<0.01)。[结论]青白栓可有效地用于实验性UC的治疗。[Objective]To observe the effect of Qingbai suppository in treating experimental ulcerative colitis in rats. [Methods]The ulcerative colitis（UC） model in rats was made by DNCB and acetic acid. The model was successfully confirmed by the pathological section, then the model rats were randomly divided into five groups ; three Qingbai groups treated with Qingbai suppository in different concentrations, model group and SASP treatment group. Meanwhile a normal control group was designed. Different groups were given different treatment respectively. Twenty days later,all animals were sacrificed. Intestines weight index,body weight, SOD, MDA, IL-2, IL-6, TNF-α, IgA and IgM of all the groups were assayed. [Results] In the groups of Qingbai with high and middle dose, the level of SOD in colon tissue significantly increased , and the tissue level of MDA markedly decreased（P〈0. 01）. The levels of serum IL-2, IL-6 and TNF-α were significantly increased in the group of Qingbai with high dose （P〈0. 05, 〈0. 01）. [Conclusion ]Qingbai suppository is effective in treating UC in rats.

关 键 词：结肠炎 溃疡性 青白栓 大鼠 

分 类 号：R574.62[医药卫生—消化系统]