胶束对几种Cu（Ⅱ）─氨基酸络合物SOD样活性的影响  

THE EFFECT OF MICELLAR ON THE SOD- LIKE ACTIVITTES OF SEVERAL Cu(Ⅱ)-AMINO ACID COMPLEXES

作　　者：金虬[1] 程志明[1] 李大珍[1] 

机构地区：[1]北京师范大学化学系

出　　处：《北京师范大学学报（自然科学版）》1996年第3期362-366,共5页Journal of Beijing Normal University(Natural Science)

基　　金：国家自然科学基金

摘　　要：测定了阳离子型表面活性剂ＣＴＡＢ和阴离子表面活性剂ＳＤＳ在磷酸缓冲溶液（ｐＨ＝７．８）中的临界胶束浓度ＣＭＣ将自行制备的数种作为ＳＯＤ模拟物的Ｃｕ（Ⅱ）氨基酸络合物分别置于胶束体系中，在ｐＨ＝７．８及（２０．０±０．５）℃条件下，用细胞色素Ｃ法测定了其对超氧阴离子自由基Ｏ歧化反应的催化活性。实验结果表明：当Ｃｕ（Ⅱ）－氨基酸络合物置于胶束体系后，除少数例外，ＳＯＤ活性大多有所提高，其中以ＣＴＡＢ所形成的胶束对于提高Ｃｕ（Ⅱ）－氨基酸络合物的ＳＯＤ样活性作用最为显著。对实验结果作了初步探讨。Abstract A cationic surfactant CTAB and an anionic snrfactant SDS were measured criti cal micelle concentration in phosphate buffer (pH=7.8) solution. Several Cu(Ⅱ) - amino acid complexes as analogues of SOD were placed in micellar system to form micelle-analogues.The catalytic activities of these micelle - analogues catalyzing dismutation of superoxide aninon radical (O) were measured by cytochros C method at (2a.a±a.5)℃ and pH=7.8. The experimental results showed: the SOD - like activities of analogues of SOD in micelle (exapt few analogues of SOD) are improved.That micelle of CTAB improves the SOD -like activities of Cu(Ⅱ)-amino acid complexes is very obvious. The experimental results were discussed.

关 键 词：模拟物 氨基酸 SOD样活性 铜 配合物 胶束 

分 类 号：R977.4[医药卫生—药品] O614.121[医药卫生—药学]