麦麸酶解产物对糖尿病大鼠肝脏和睾丸氧化损伤的保护作用  

THE PROTECTIVE EFFECTS OF ENZYMES HYDROLYZED WHEAT BRAN ON THE OXIDATIVE DAMAGE OF LIVER AND TESTIS IN DIABETIC RATS

作　　者：焦霞[1] 陈静[2] 欧仕益[1] 葛丽霞[2] 周红锋[1] 

机构地区：[1]暨南大学食品科学与工程系,广州510632 [2]暨南大学医学院营养教研室,广州510632

出　　处：《营养学报》2007年第1期78-81,共4页Acta Nutrimenta Sinica

基　　金：广州市科技攻关引导项目(No.2003Z3-E0061)

摘　　要：目的:观察麦麸酶解产物(EHWB)对糖尿病大鼠肝脏和睾丸的抗氧化作用。方法:用四氧嘧啶制备SD大鼠糖尿病模型,以EHWB 19.36mg/kg bw.d灌胃,维生素C(VC)10.42mg/kg bw.d灌胃作对照,测定各实验组大鼠血糖,肝脏和睾丸总抗氧化能力(T-AOC)及超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)和黄嘌呤氧化酶(XOD)活性及丙二醛(MDA)含量。结果:与糖尿病组相比,EHWB治疗组大鼠血糖明显降低(P<0.01=,肝脏和睾丸T-AOC能力增强(P<0.01),GSH-Px和SOD活力增强(P<0.05),XOD活性和MDA含量降低(P<0.05)。EHWB治疗组大鼠肝脏和睾丸T-AOC能力明显高于VC组(P<0.01),肝脏XOD活性低于VC组(P<0.01)。结论:EHWB具有降血糖和提高糖尿病大鼠组织抗氧化能力,其效果强于传统抗氧化剂VC。Objective： To observe the antioxidative function of enzymes-hydrolyzed wheat bran （EHWB） on liver and testis in diabetic rats. Methodi Diabetes mellitus was induced by alloxan injection. EHWB was given intragastrically （ig）, and vitamin C （VC） was given as control group. The level of blood glucose, the total antioxidative capacity （T-AOC）, the activity of superoxide dismutase （SOD）, glutathione peroxidase （GSH-Px）, and xanthine oxidase （XOD）, and the content of malondiadehyde （MDA） were detected respectively in liver and testis. Results： EHWB significantly decreased the level of blood glucose and increased the level of T-AOC, as well as the activity of GSH-Px and SOD, but decreased the activity of XOD and the content of MDA in liver and testis of diabetes rats. The level of T-AOC in liver and testis of rats fed EHWB was higher and the activity of XOD in liver was lower than those in rats fat VC. Conclusion： EHWB can effectively decrease the level of blood glucose and increase antioxidative effects of diabetic rats, and the effects are stronger than VC.

关 键 词：麦麸酶解产物 糖尿病 肝脏 睾丸 抗氧化 

分 类 号：R587.1[医药卫生—内分泌]