非小细胞肺癌三维适形放射治疗临床研究  

Three dimensional conformal radiotherapy for non-small-cell lung cancer

作　　者：姚春筱[1] 张树平[1] 陈保民[1] 崔淑敏[1] 王玉瑛[1] 高强[1] 

机构地区：[1]山西省人民医院放射治疗科,太原030012

出　　处：《肿瘤研究与临床》2007年第2期96-98,共3页Cancer Research and Clinic

基　　金：基金项目：山西省卫生厅科技基金项目（200131）.

摘　　要：目的比较三维适形放射治疗（3DCRT）和立体定向放射治疗（SRT）圆形准直器系统治疗非小细胞肺癌（NSCLC）的临床疗效。方法64例NSCLC患者随机分为治疗组（3DCRT组）和对照组（SRT组），均常规放射治疗40Gy后，再分别应用3DCRT和SRT加量照射，两组均为4～5Gy／次，6—7次，隔日1次，每周3次，总量28～35Gy，2～3周完成。结果3DCRT组和SRT组有效率分别为87．9％和64．5％，差异有统计学意义；3DCRT组和SRT组1、2、3年生存率分别为74．6％、51．5％、36．2％和71．2％、48．9％、26．5％。中位生存时间分别为23和18个月，差异均无统计学意义；3DCRT组和SRT组正常组织并发症发生率（NTCP）分别为27．3％和48．4％，差异有统计学意义。结论3DCRT可有效提高NSCLC患者肿瘤局部控制率和生存质量。Objective To compare the clinical effects of three dimensional conformal radiotherapy （3DCRT） and stereotactic radiotherapy（SRT） for non-small-cell lung cancer（NSCLC）. Methods 64 patients with NSCLC were randomized dividing into two groups, one was 3DCRT group, the other was SRT group, and a 40 Gy conventional fractionation irradiation was given to them. 3DCRT and SRT were started as a boost. The irradiation dose of dose-escalation treatment plan ranged from 28 Gy to 35 Gy, and were delivered in fractions of 4 - 5 Gy, 3 days a week. Results In 3DCRT group, twelve patients achieved CR, 17 PR, 3 NR and 1 PD, with a total response rate of 87.9 %（29/33）. The 1-, 2- and 3-year survival rates were 74.6 %, 51.5 % and 36.2 %. The middle-survival time was 23 months. In SRT group, seven patients achieved CR, 13 PR, 8 NR and 3 PD, with a total response rate of 64.5 %（20/31）. The 1-, 2- and 3-year survival rates were 71.2 %, 48.9 % and 26.5 %. The middle-survival time was 18 months. NTCP of 3DCRT group is 27.3 % （9/33）, and SRT is 48.4 %（15/31）. Conclusion 3DCRT can improve local control rate and survival quality for NSCLC.

关 键 词：癌 非小细胞肺 放射疗法 适形 

分 类 号：R730[医药卫生—肿瘤] R734[医药卫生—临床医学]