Skp2在急性白血病中的表达及其与p27（kip1）和Ki67的关系  

Expression of Skp2 in patients with acute leukemia and its relationship with p27（kip1） and Ki67

作　　者：孙慧[1] 韩利杰[2] 孙玲[1] 

机构地区：[1]郑州大学第一附属医院血液科 ,450052 [2]郑州市第三人民医院血液科

出　　处：《白血病．淋巴瘤》2007年第1期12-14,共3页Journal of Leukemia & Lymphoma

摘　　要：目的探讨S期激酶相关蛋白2（Skp2）在急性白血病中的表达及其与p27（kip1）蛋白和增生相关抗原Ki67的关系。方法采用免疫细胞化学法检测三者在初治急性非淋巴细胞白血病患者、急性淋巴细胞白血病患者及正常对照者骨髓单个核细胞中的表达。结果初治急性白血病患者中Skp2和Ki67的表达水平明显高于对照组（均P〈0．01），p27（kip1）的表达水平明显低于对照（P〈0．05），以上各指标在急性非淋巴细胞白血病和急性淋巴细胞白血病之间差异无统计学意义（P〉0．05），且Skp2与p27（kip1）、Ki67的表达分别呈负相关（rs=-0．489，P〈0．05）、正相关（rs=0．609，P〈0．01）。结论Skp2异常增高可能通过促进p27（kip1）的降解而参与了白血病的发生，并与细胞增生相关抗原Ki67正相关。Objective To explore the expression of Skp2 in acute leukemia and its relationship with cyclin dependent kinase inhibitor p27 （kipl） and proliferative antigen Ki67. Methods The expressions of Skp2, p27（kipl） and Ki67 in bone marrow mononuclear cells from untreated acute leukemia patients and control were detected by immunocytochemical staining. Results The expressions of Skp2 and Ki67 were significantly higher in patients than in control （P 〈0.01） and the expression of p27（kipl） was significantly lower in patients than in control （P 〈0.05）, and no significant difference of Skp2, p27（kipl） and Ki67 was seen between acute nonlymphocytic leukemia and acute lymphocytic leukemia（P 〉0.05）. The expression of Skp2 was correlated with that of p27（kipl） negatively （rs = -0.489, P 〈0.05）, and Ki67 positively （rs = 0.609, P 〈0.01） respectively. Conclusion Abnormally high Skp2 played a role in the leukemogenesis through enhancing the degradation of p27（kipl） and was related to Ki67 positively.

关 键 词：白血病 淋巴细胞 急性 白血病 非淋巴细胞 急性 S期激酶相关蛋白质类 KI67抗原 蛋白质p27(kip1) 

分 类 号：R733[医药卫生—肿瘤]