药用缓释材料聚乳酸-乙醇酸共聚物的研制  

Study and preparation on poly(lactic-glycolic acid) polymer as medicinal delivery material

作　　者：刘苗苗[1] 张政朴[2] 

机构地区：[1]天津市计划生育研究所,天津300191 [2]南开大学高分子化学研究所,天津300070

出　　处：《天津药学》2007年第1期13-15,共3页Tianjin Pharmacy

摘　　要：目的：合成药用聚乳酸-乙醇酸高分子缓释材料，用于某些生物药物缓、控释剂型的制备；同时探讨聚合反应条件的影响因素以及优化工艺。方法：在一定的温度和压力下，采用配位-插入聚合法通过交酯开环合成聚乳酸-乙醇酸共聚物缓释材料。结果：本研制合成的聚乳酸-乙醇酸共聚物（PLGA75／25和PLGA50／50）经采用多种鉴定手段表征化学结构正确，力学性能良好，玻璃转化温度为33．7℃，分子量为27000～70000，分子量分布为1．4～1．6，产品最终产率可达70％以上。结论：通过制备工艺条件的控制和优化，在一定范围内，不仅可以得到分子量大小不等和单体比例不同的聚乳酸-乙醇酸缓释材料，而且每批次之间所得分子量重现性良好，合成工艺稳定、可靠。OBJECTIVE To synthesize a kind of medicinal polylactic - glycolic aciddelivery material for preparation of delivery microspheres of peptide and protein; We made inquiries into influential factors of polymerized condition and the technical improvement simultaneously. METHODS Under specified temperature and press, adopt coordination - insertion mechanisms by a ring - opening polymerization process. RESULTS The consist of PLGA（75/25,50/50） were tested through several methods of examination, glass temperature（Tg） is 33.7 ℃ ,molecule weight（ Mw） range is 27 000 -70 000,Mw dispersion is between 1.4 - 1.6 and the yield of products was more than 70%. CONCLUSION Through to control and improve the polymerization condition, we have got PLGA polymer of different Mw, the repeatability of preparation technology is well.

关 键 词：高分子缓释材料 聚乳酸-乙醇酸 共聚物 

分 类 号：R914.4[医药卫生—药物化学]