血管内皮细胞表面Ⅳ型胶原酶表达研究  

STUDIES ON TYPE Ⅳ COLLAGENASE PRESENTING IN THE HUMAN ENDOTHELIAL CELLS

作　　者：吴金莺[1] 冯麒 吴信法[2] 

机构地区：[1]上海铁道大学附属甘泉医院中心实验室,上海200065 [2]上海铁道大学医学院基础医学部病理生理教研室,上海200070

出　　处：《上海铁道大学学报（医学版）》1996年第2期95-96,共2页

摘　　要：血管内皮细胞在血管构筑、基底膜更新修复以及肿瘤组织内的血管生长调控中起重要作用。为进一步了解Ⅳ型胶原酶与内皮细胞、血管外间质之间的相互关系,本文用体外培养的内皮细胞作免疫细胞化学染色,观察内皮细胞表面Ⅳ型胶原酶分布与表达。研究结果表明,人血管内皮细胞具有合成和表达Ⅳ型胶原酶的功能,并对此作了进一步的讨论。Vascular endothelial cell plays an important role in vascular construction, basement membrane remodle and control over the vascular growth in tumor tissues. In order to study the relationship between type Ⅳ collagenase,endothelium and extravaalar matrix ,the cultured human umbilical vein cells in vitre were used to observe the expression and distribution of type Ⅳagenase with the method of immunocytochemistry. The result showed that human vascular endothelium has the function ofyhnthesis and expression of type Ⅳ collagenase and the discussion is also given in this article.

关 键 词：免疫细胞化学 B-FGF IL-1 血管内皮细胞 

分 类 号：R363.14[医药卫生—病理学]