新生期小鼠辣椒素处理对针刺调节免疫反应的影响  

The Effects of C-fibers of Primary Afferent on Immune Responses Regulated by EA in Mice

作　　者：赵建础[1] 刘文琴[1] 赵续民[1] 张晓彬[1] 赵岗[1] 赵爱玲 薛峰 

机构地区：[1]陕西省中医药研究院,西安710003

出　　处：《针刺研究》1996年第3期36-41,共6页Acupuncture Research

基　　金：国家自然科学基金

摘　　要：本工作表明电针可增强正常动物的多种免疫反应功能。为了从机能上确定在免疫反应中电针的调节作用是否与初级感觉传入C-纤维有关，我们用辣椒素（cap）作为选择性损毁初级传入C-纤维的一种工具药物，新生期小鼠50mg/kg皮下注射，成年后发现该动物多种免疫反应的基础水平发生明显改变。除了血清IgG降低外，其它多种细胞免疫和体液免疫反应如脾重、胸腺重、PFC、LTT、IL－2和血凝抗体液度与赋形剂对照组比较，皆有明显的提高。给cap处理的动物电针后，该组动物的免疫水平与cap对照组基本相同。电针所调节的免疫反应效应在cap处理的动物上未能看到。提示电针对免疫反应的调节作用与cap敏感的传入C-纤维有关。This work showed that electroacupuncture(EA) could enhance the ability of mhltiple irnmune re-sponses in vehicle-treated animals. To study the role of primary sensory afferent C-fibers in the effectof EA on immume response, the experiments were performed on adult mice treated by capsaicin (cap)(50mg/kg) in neonate, cap is a tool drug selectively impairing afferent C-fibers. We found that thebasal levels of multiple immune responses were changed apparently, showing that except the serumIgG decreased, all the spleen weight, thymus weight, spleen PFC, LTT, IL-2 and hemoagglutinatingantibody titer elevated obviously in cap-treated mice as compared to that in vehicle control group.After the cap-treated mice were given EA, the levels of immune responses were found to be idehti-cal with cap-treated control group. The effects of EA-regulated immune response in vehicle-treatedmice could not be observed in the cap-treated mice. The results mentioned above indicated that the ef-fects of EA-regulated immune response were related to cap-sensitive afferent C-fibers.

关 键 词：辣椒素 电针 免疫调节 

分 类 号：R245.97[医药卫生—针灸推拿学]