雷贝拉唑与奥美拉唑对老年人反流性食管炎的抑酸效能及其症状缓解作用比较  

Comparison on relief of symptoms and acid suppression of Rabeprazole and Omeprazole on reflux esophagitis in aged

作　　者：夏俊[1] 郑松柏[1] 于晓峰[1] 姚健凤[1] 赵尚敏[1] 

机构地区：[1]复旦大学附属华东医院消化内科,上海200040

出　　处：《老年医学与保健》2007年第1期15-17,共3页Geriatrics & Health Care

摘　　要：目的比较雷贝拉唑和奥美拉唑对老年人反流性食管炎(RE)的抑酸效果及症状缓解作用。方法60例经胃镜检查确诊为反流性食管炎的老年患者,随机分成两组,每天早餐前空腹口服雷贝拉唑10mg或奥美拉唑20mg,疗程均为7d。在用药前和用药后的第1天及第7天对患者的主要反流症状进行症状学评分,比较两组治疗前后症状学评分。每组各选10名患者于服药第1天做24h胃内pH值监测,比较这两种药物胃酸抑制效果。结果服药第1天雷贝拉唑组的症状评分为1.86±1.17,奥美拉唑组为2.53±1.14,P<0.05。雷贝拉唑组7人症状消失,奥美拉唑组的2人症状消失。至第7天两组的症状评分分别为0.47±0.68和0.63±0.72,症状消失率分别为63.3%和50%,两组差异无统计学意义。服药第1天雷贝拉唑组服药后2h胃内中位pH值为6.10±1.13,高于奥美拉唑组的4.22±2.38,起效时间40.8±24.35,快于奥美拉唑组的112.0±105.46,P值均小于0.05。其余各项指标差异无统计学意义。两组均无明显不良反应事件发生。结论雷贝拉唑和奥美拉唑对老年人RE患者均有良好的抑酸效能及症状缓解作用,但雷贝拉唑起效更快、抑酸作用更稳定。Objective To compare the effects of Rabeprazole and Omeprazole in relief of reflux esophagitis symptoms and acid suppression in elderly patients, Methods Sixty elderly patients suggestive of RE confirmed by endoscope were enrolled. All patieats were raudomly divided iuto two groups, Each group was received rabepcazole 10mg or omeprazole 20mg once daily for 7 days, respectively. The score of typical reflux symptoms was observed before and after treatment. To assessed acid suppression 10 patients in each group underwent continuous 24 hours gastric pH monitoring at the first day. Results On day 1 of treatment, The symptom score of rabeprazole group was 1.86 ± 1.17 and omeprazole group was 2.53 ± 1.14.（P〈0.05）. The disappearance rate of reflux symptoms after one day treatment were 6.7 %（2,OPZ） and 13.3%（7,RPZ）, respectively. After 7 days, The symptom score of two groups were 0.47 ± 0.68 and 0.63 ± 0.72, respectively. The disappearance rate of reflux symptoms were 50% and 63.3%. No difference was found between RPZ and OPZ groups. On first day of treatment, the intragastric 2-h median pH after drug administration in RPZ group compared with thus in OPZ group： 6.10 ± 1.13 versus 4.22 ± 2.38, respectively, the difference was statistically significant. The onset times of rabeprazole was significantly lower than those of omeprazole（40.8 ± 24.35 versus 112.0 ± 105.46, P〈0,05）.For the intra-gastric 24-h median pH value and percentage of pH〉4, there were no difference between RPZ group and OPZ group. No obvious adverse events were observed in both groups. Conclusions Omeprazole and rabeprazole also revealed a sufficient effect of gastric acid suppression and reflux symptoms relief. Raheprazole provided significantly faster acid suppression.

关 键 词：雷贝拉唑 奥美拉唑 食管炎 消化性 老年人 

分 类 号：R571[医药卫生—消化系统]