动脉内灌注化疗治疗化放疗未控或复发食管癌  

Arterial perfusion chemotherapy in the treatment of uncontrolled or recurrent esophageal carcinoma after chemotherapy or radiotherapy

作　　者：郭宏强[1] 宋太民[1] 牛松涛[1] 马会军[1] 张耀勇[1] 曹永新[1] 马桂贞[1] 

机构地区：[1]漯河市中心医院肿瘤科,河南漯河462000

出　　处：《中国介入影像与治疗学》2007年第1期31-34,共4页Chinese Journal of Interventional Imaging and Therapy

基　　金：河南省医药卫生重点科研课题研究项目(97-183)。

摘　　要：目的评价食管癌动脉内灌注化疗对化放疗未控或复发食管癌的近期疗效。方法对29例化放疗未控或复发的食管癌患者,采用Seldinger技术进行肿瘤供血靶动脉的选择性插管和造影,并经导管灌注化疗药物。结果29例患者经动脉灌注化疗后近期疗效为:完全缓解2例,部分缓解18例,无变化5例,进展4例,总有效率(PR+CR)为69.0%。本组经治疗后80%患者吞咽困难、声嘶、咽麻痹症状缓解。4例食管闭塞患者治疗后能进普食。3例呼吸困难患者,治疗后均见缓解。结论动脉内灌注化疗治疗化放疗未控或复发食管癌是一种有效的方法。Objective To evaluate the effect of arterial perfusion chemotherapy in the treatment of uncontrolled or recurrent esophageal cancer after chemotherapy or radiotherapy. Methods Twenty-nine cases with uncontrolled or recurrent esophageal cancer after chemotherapy or radiotherapy were treated with selective transcatheter arterial perfusion with Seldinger technique. Results Of 29 cases after arterial perfusion, 2 cases were achieved complete response （CR）, 18 cases were partial response （PR）, 5 cases with stable disease （SD） and 4 cases with progressed disease （PD）. The total response was 69.0%. 80% cases with dysphagia, hoarseness, pharyngeal paralysis were achieved remission. Four cases with esophageal emphraxis could have normal diet. Three cases with dyspnea were gained remission. Conclusion It is an effective method to treat uncontrolled or recurrent esophageal cancer after chemotherapy or radiotherapy with arterial perfusion.

关 键 词：食管癌 化疗 放疗 动脉灌注 

分 类 号：R735.1[医药卫生—肿瘤] R815[医药卫生—临床医学]