大鼠急性脑缺血扩散张量成像各参数变化的实验研究  

Diffusion tensor imaging parameters dynamic change in acute cerebral ischemia of rats: experimental study

作　　者：杨艳梅[1] 冯晓源[1] 倪建明[1] 姚振威[1] 蒋胜洪[1] 于同刚[1] 

机构地区：[1]复旦大学华山医院放射科,上海200040

出　　处：《中国医学影像技术》2007年第2期184-187,共4页Chinese Journal of Medical Imaging Technology

摘　　要：目的明确急性脑缺血扩散张量成像DCav、Iso image、FA、RA值的动态变化。方法清洁级健康雄性SD大鼠12只，分成四组：A组MCAO脑缺血1h（3只），B组脑缺血1．5h（3只），C组脑缺血3h（3只），D组脑缺血6h（3只）。按照时间点行脑MR检查，测量病变和对侧相应区域Isoimage信号、DCav、FA、RA值。结果脑缺血各观察时间点MRI显示患侧脑皮质和纹状体等皮质下结构DCav值降低至对侧的51％～67％，各向同性图像Iso显示明确的病侧异常高信号。在MCAO1h和1．5h虽然患侧FA、RA测量值偏高，但与对侧不具备统计学差异。脑缺血3h时患侧FA、RA值降低，与对侧差别有显著意义，此种现象持续至6h。结论急性脑缺血不同MRDTI参数随时间变化各异，联合应用能全面反映缺血组织病理生理状态。Objective To definitude the dynamic changes of Iso image, DCav, FA, RA value in acute cerebral ischemia. Methods Twelve male SD rats were divided into four groups randomly： group A： MCAO 1 h （3 rats）, group B： MCAO 1.5 h （3 rats）, group C： MCAO 3 h （3 rats）, group D： MCAO 6 h （3 rats）. The value of Iso image signal, DCav, FA and RA in the lesion and control region were measured. Results The DCav value of left cortical and striatal area were lowered grading 51%- 67 % and the isotropic image showed hyperintensity significantly in all times. After cerebral ischemia 1 h and 1.5 h the FA and RA value in left MCA territory were heightened slightly, but had no significance with contralateral region. In 3 h and 6 h the FA, RA value of left MCA territory dropped. Conclusion The MR DTI parameters changes were luxuriant in acute cerebral ischemia. The combination of these parameters could help to reflect the pathophysiological state entirely.

关 键 词：脑缺血 磁共振成像 扩散张量成像 

分 类 号：R-332[医药卫生]