固定小动物脑标本单次激发回波平面扩散张量成像中磁化率伪影的控制  

Formalin-fixed small animal brains magnetic susceptibility artifact control in single shot echo planar diffusion tensor imaging

作　　者：李坤成[1] 张帆[1] 于春水[1] 秦文[1] 杨延辉[1] 

机构地区：[1]首都医科大学宣武医院医学影像部放射科,北京100053

出　　处：《中国医学影像技术》2007年第2期281-283,共3页Chinese Journal of Medical Imaging Technology

基　　金：国家自然科学基金项目(30470519);北京市科技新星项目(2005B21)。

摘　　要：目的探讨福尔马林固定的小动物脑标本在单次激发回波平面扩散张量成像中如何通过合适的放置方法减少由于磁化率效应诱导的解剖结构的几何变形。方法运用3T磁共振扫描仪和正交腕关节线圈,采用单次激发回波平面扩散张量成像序列扫描猫、大鼠脑标本,观察何种放置方法获得的DTI图像相对于常规T2加权图像有最小的几何变形。结果将标本浸入装有溶液的容器的中央,用支架托起和丝网分别托起的猫和鼠脑标本DTI图像与常规T2图像比较没有明显的几何变形。结论运用合适的放置方法可以获得理想的固定小动物脑标本DTI成像效果。Objective To study method which could control magnetic susceptibility artifact in single shot echo planar diffusion tensor imaging for formalin-fixed small animal brains. Methods Formalin-fixed rat and cat brains was examined on a 3.0 Tesla MR scanner with a quadrature wrist joint coil using single shot echo planar diffusion tensor imaging. Observing how to place brain tissue could decrease geometry deformation of DTI comparing T2WI. Results Comparing with T2WI, using plastic stand and silk screen holding cat and rat brain did not have conspicuous geometry deformation. Conclusion Using suitable placing method can get better diffusion imaging of formalin-fixed small animal brain.

关 键 词：单次激发回波平面成像 磁化率伪影 

分 类 号：R-332[医药卫生]