心前区放疗诱发心脏疾病21例临床分析  

Clinical analysis of 21 cases of radiation-induced heart disease

作　　者：涂文勇[1] 戴峰[1] 刘璐[1] 

机构地区：[1]东南大学核医学基础研究所,南京210003

出　　处：《中国肿瘤临床与康复》2007年第1期29-30,共2页Chinese Journal of Clinical Oncology and Rehabilitation

摘　　要：目的探讨放射线引起与诱发心脏疾病的临床特点与诊治。方法收集心前区放疗诱发心脏病患者21例，中位随访期13个月，对其临床特点、诊断及病理改变进行分析。结果放疗6个月后，患者临床症状明显增加。心悸19例，呼吸困难20例，胸痛17例，心源性哮喘7例，心电图发现心律失常12例，心功能Ⅲ期17例，心功能Ⅳ级4例。心脏毒性在SOMA1～3级。结论胸部放疗中，放射线引起与诱发的心脏疾病是要考虑的重要因素。Objective To explore the clinical syndrome and diagnosis of radiation-induced heart disease （RIHD）. Methods Between 1990 and 2000, 21 patients suffered from RIHE in Nanjing tumor hospital. The median follow-up period was 13 months. Results Patients had significantly increased clinical symptoms in six months after radiotherapy. Palpitation, dyspnea, chest pain, cardiac asthma, arrhythmia, heart function at stage Ⅲ occurred in 90. 1% （ 19/21 ）, 95.2% （20/21） ,81.0% （ 17/21 ） ,33.3% （7/21）, 57.2% （ 12/21 ） and 81.0% （ 17/21 ） of the patients respectively. Cardiac toxicity of these patients was evaluated as SOMA grade 1-3. Conclusions RIHD might be an important factor which should be considered in selecting patients for chest radiotherapy.

关 键 词：放射损伤 心脏 

分 类 号：R730.5[医药卫生—肿瘤]