猪腹部火器伤肠管穿透后肝脏功能和形态的变化  

Changes of hepatic morphology and function following intestinal perforation due to abdominal firearm wound in pigs

作　　者：李泽信[1] 冯德元[2] 张永久[2] 刘江伟[2] 闫兵[2] 梁晓莉[2] 张雷华[2] 吴辉[2] 

机构地区：[1]石河子大学医学院,新疆石河子832000 [2]兰州军区乌鲁木齐总医院普外科,新疆乌鲁木齐830000

出　　处：《中国现代普通外科进展》2007年第1期45-47,共3页Chinese Journal of Current Advances in General Surgery

基　　金：兰州军区医药卫生科研基金资助项目(LXH-2005019)

摘　　要：目的:观察腹部火器伤肠管穿透后肝脏功能和形态的变化。方法:健康长白仔猪42头随机分为对照组以及伤后1h、2h、4h、8h、12h和24h组,实验组建立腹部火器伤肠管穿透模型后,分别测定伤后1h、2h、4h、8h、12h和24h各组动物血清中ALT、AST水平,并与对照组比较,观察实验组各时间点肝脏组织学变化。结果:伤后各组血清ALT、AST水平均高于对照组,并于伤后2h和12h出现2个高峰。伤后1h、2h、4h组出现逐渐加重的肝细胞水肿、变性,伤后8h、12h、24h组出现逐渐加重的肝细胞点状坏死、灶状坏死、炎细胞浸润。对照组光镜下未见明显的损伤性变化。结论:腹部火器伤肠管穿透导致肝脏出现功能和形态的损伤性变化,随着伤后时间的延长而加重。Objective：To investigate the changes of hepatic function and morphology in abdominal firearm wound pigs. MeSA total of 42 Chang-Bai piglets were randomized into 7 group s＇control group and Ih group, 2h group, 4h group, 8h group, 12h group, 24h group.The model of penetrating abdominal firearm wound was established in wounded groups. Serum ALT, AST levels were determined. The alter ations of hepatic tissue were observed. Results：Levels of serum ALT and AST were significantty elevated compared to control group in wounded groups,and they ap peared two peaks in 2h group and 12h group（P〈0.01）.Observing under light microscope,hepatocytes edema and metamorphosis were gradually aggravated from 1 h group to 4h group. Hepatocytes spot necrosis and piecemeal necrosis were observed in 8h group, and increasing from 8h group to 24h group. Conclusion：ntestinal perforations due to abdominal firearm wound evoke hepatic functional and morphological injury, which aggravates with prolongation of wound.

关 键 词：腹部损伤 穿透性 创伤 抢击 肝 猪 

分 类 号：R575[医药卫生—消化系统]