牙周状况、血清白细胞介素-1β水平与妊娠关系初探  

A Pilot Study on Relationship of Periodontal Status,Serum Level of Interleukin-1β and Delivery Outcomes in Pregnant Women

作　　者：李晓军[1] 孔经贾[1] 梁峰冰[2] 陈晖[1] 贺晶[2] 

机构地区：[1]浙江大学口腔医院口腔内科 [2]浙江大学医学院附属妇产医院产四科,浙江杭州310006

出　　处：《华西口腔医学杂志》2007年第1期61-63,共3页West China Journal of Stomatology

基　　金：浙江省医药卫生科学研究基金资助项目(2002A062)

摘　　要：目的探讨牙周状况、血清白细胞介素-1β(IL-1β)水平与妊娠间的关系。方法以40例先兆早产孕妇(TPL组)和40例正常孕妇(Non-TPL组)为研究对象,检查全口牙齿的牙周状况,记录菌斑指数(PLI)、探诊深度、临床附着丧失和出血指数(BI),并计算牙周炎位点率。酶联免疫吸附试验检测血清IL-1β水平。对各项检查指标进行统计分析。结果①TPL组40例孕妇中26例足月产(TPL-TB小组),14例早产(TPL-PB小组);Non-TPL组40例孕妇皆足月产。TPL组和Non-TPL组、TPL-TB小组和TPL-PB小组的分娩孕周、新生儿出生体重、PLI、牙周炎位点率和血清IL-1β水平间的差异均有统计学意义(P<0.05)。②分娩孕周和牙周炎位点率、BI、IL-1β水平呈负相关(P<0.05),IL-1β水平与牙周炎位点率和BI呈正相关(P<0.05)。结论牙周感染可能是早产的原因之一。Objective To evaluate the associations between periodontal conditions, serum level of interleukin-1β （IL-1β） and delivery outcomes in pregnant women with a diagnosis of threatened premature labor（TPL）. Methods Eighty systemically healthy pregnant women were enrolled in the study. The ease group was composed of 40 pregnant women hospitalized with the diagnosis of TPL （TPL group） and the control group was composed of 40 normal pregnant women （Non-TPL group）. Periodontal examinations included assessments of plaque index （PLI）, clinical attachment loss （CAL）, probing depth （PD）, bleeding index （BI） and the perccnt of periodontitis sites （PD〉3 mm, CAL≥2 mm）. The serum level of IL-1β was determined using commercially available enzyme-linked immunoassays. Results ①Fourteen of forty subjects of TPL group delivered premature labor infants （TPL-TB group）, and twentysix subjects delivered natural labor infants （TPL-PB group）. No infants were delivered as premature labor infants in non-TPL group. There were significant differences in gestational age at delivery, birth weight, PLI, percentage of periodontitis sites and IL-1β levels between the non-TPL group and TPL group or between the TPL-TB group and TPL-PB group （P〈0.05）.②Significant negative correlation were observed between the gestational age at delivery and percentage of periodontitis sites as well as serum IL-1β levels （P〈0.05）. And significant positive correlation were observed between percentage of periodonfitis site and serum IL-1β levels （P〈0.05）. Conclusion Periodontal inflammation might be one of the pathogenesis of preterm birth.

关 键 词：牙周病 妊娠 白细胞介素-1Β 

分 类 号：R781.4[医药卫生—口腔医学]