脑波治疗对老年期抑郁症患者认知损害P300的影响  

Effects of brain wave therapy on cognitive impairment P300 in the senile depression

作　　者：周振和[1] 朱红梅[1] 曹淑霞[2] 侯永华[3] 程灶火[4] 李恒芬[2] 

机构地区：[1]南京医科大学附属无锡精神卫生中心精神科,江苏无锡214151 [2]河南省新乡医学院第二附属医院老年精神科 [3]河南省新乡医学院第二附属医院诱发电位室 [4]中南大学湘雅第二医院

出　　处：《中国老年学杂志》2007年第4期336-338,共3页Chinese Journal of Gerontology

基　　金：河南省教育厅自然科学研究课题(No.20023200017)

摘　　要：目的探讨脑波治疗对老年期抑郁症患者认知损害的听觉诱发事件相关电位P300(ERP-P300)的影响。方法将60例(年龄≥60岁)符合《中国精神障碍分类与诊断标准第3版》抑郁症诊断标准患者随机分为单纯应用氟西汀治疗组(氟西汀组)及应用脑波联合氟西汀治疗组(联合组),对两组在治疗8w前后进行ERP-P300检测及汉密顿抑郁量表(Hamiltonratingscalefordepression,HAMD)评定。另选择性别、年龄以及文化程度相匹配的正常老年人60例作为对照组。比较各组之间ERP-P300潜伏期、波幅以及反应时间的差异。结果与对照组相比,治疗前氟西汀组、联合组P2、N2、P3潜伏期及反应时间明显延长,P2、N2、P3波幅明显降低(P<0.05或P<0.01)。治疗后,氟西汀组P2、N2潜伏期及反应时间比治疗前明显缩短,P2、N2、P3波幅明显增高(P<0.05或P<0.01);联合组P2、N2、P3潜伏期及反应时间比治疗前明显缩短,P2、N2、P3波幅明显增高(P<0.05或P<0.01)。治疗后,氟西汀组P3潜伏期及反应时间比联合组明显延长(P<0.05或P<0.01);氟西汀组HAMD评分明显高于联合组(P<0.01)。结论脑波治疗通过调节、平衡人体的脑电活动及兴奋水平,具有改善老年期抑郁症患者认知功能的作用。Objective To study the effects of brain wave therapy on cognitive impairment P300 in the senile depression. Methods Sixty patients （no less than 60 years old） met with CCMD-3 for Depression criteria were divided into fluoxetine, treated group （fluoxetine group） and brain wave therapy combined fluoxetine treated group （united group） randomly. Another 60 healthy persons marched for sexual, age and educted degree were selected as control group. All groups were assessed with HAMD and auditory evoked event-related potential P300 before and after 8 weeks treatment. P300 latency, amplitude and reactive time of all groups were compared with each other before and after treatment respectively. Results The latency and reactive time of P2, N2,and P3 prolonged and the amplitude of P2, N2 and P3 shortened in fluoxetine group and united group compared with those in control group （P 〈0. 05 or P 〈0. 01 ）. After treatment,the latency and reactive time of P2, N2 shortened and the amplitude of P2, N2 and P3 hoisted compared with those before treatment in fluoxetine group （ P 〈 0. 05 or P 〈0. 01 ） ;the latency and reactive time reduced and the amplitude of P2, N2 and P3 hoisted compared with those before treatment in united group （ P 〈 0.05 or P 〈 0. 01 ）. The latency and reactive time of P3 in fluoxetine group prolonged compared with united group （ P 〈 0.05 or P 〈 0.01 ） ;The HAMD scores of fluoxetine group were more than that in united group after treatment （P 〈 0.01 ）. Conclusions Brain wave therapy could improve the cognitive function in the senile depression by adjusting and balancing brain electric activity and excited level.

关 键 词：老年期抑郁症 事件相关电位P300 认知功能 脑波治疗 汉密顿抑郁量表(HAMD) 

分 类 号：R749.3[医药卫生—神经病学与精神病学]