肝硬化患者红细胞CD_(58)、T细胞亚群表达与胆碱酯酶相关研究  

Relationship of CD_(58) on erythrocytes,T lymphocyte subgroups and cholinesterase in patients with cirrhosis

作　　者：赖苇[1] 杨晋辉[2] 董树强[1] 杨婧[2] 唐映梅[2] 张宏英[3] 程思根[1] 

机构地区：[1]云南省昆明市第一人民医院消化内科,云南昆明650011 [2]云南省昆明医学院第二附属医院肝胆胰内科,云南昆明650032 [3]云南省昆明市东川区人民医院内三科,云南昆明654100

出　　处：《中国现代医学杂志》2007年第3期294-297,共4页China Journal of Modern Medicine

摘　　要：目的探讨肝硬化患者红细胞CD_(58)、T淋巴细胞与CHE的关系。方法用流式细胞仪检测48例肝硬化患者及30例正常对照者的红细胞CD_(58)、CD_3、CD_4、CD_8及CD_4/CD_8值,同时检测血清CHE。结果肝硬化患者红细胞CD_(58)显著高于正常对照组(P<0.01),CD_4及CD_4/CD_8值明显低于正常对照组而CD8明显升高(P<0.01),肝硬化组CHE较对照组明显降低(P<0.01);红细胞CD_(58)升高与CD_4(r=-0.472)、CD_4/CD8值(r=-0.477)、CHE(r=-0.582)降低呈负相关(P<0.01)、与CD_8升高呈正相关(r=0.291,P<0.01);CD_4、CD_4/CD_8值降低与CHE降低呈正相关(r=0.636、r=0.627,P<0.01),CD_8升高与CHE降低呈负相关(r=-0.389,P<0.01)。结论肝硬化患者存在红细胞免疫功能及T淋巴细胞免疫功能紊乱,红细胞CD_(58)高表达与肝脏储备功能损伤程度存在一致性,肝细胞功能异常可能与细胞免疫功能的紊乱密切相关,红细胞CD_(58)的异常严重影响机体的T淋巴细胞免疫功能。[Objective] To probe the relationship of CD58 on erythrocytes, T lymphocyte subgroups and cholinesterase in patients with cirrhosis. [Methods] We studied 48 patients with cirrhosis and 30 normal controls. Quantities of CD58 on erythrocytes, CD3 cell, CD4 T cell and CD8 cell were detect by Flow Cytometry, then we could know the rate of CD4/CD8. At the same time, serum concentration of cholinesterase was measured. [Results] In comparison to controls, expression of CD58 on erythrocytes in cirrhosis patients was significantly higher （P 〈0.01）, quantity of CD4and rate of CD4/CD8 were significantly decreased （P 〈0.01）, quantity of CD8 was significantly increased （P 〈 0.01）, serum concentration of cholinesterase was significantly decreased （P 〈0.01）. Expression of CD58 exhibited positive correlation with CD8 T cell （r =0.291, P 〈0.01）, negative correlation with CD4 T cell, rate of CD4/CD8, cholinesterase （r =-0.472, r =-0.477, r =-0.582, P 〈0.01）. Expression of CD4 T cell and the rate of CD4/CD8 exhibited positive correlation with CHE （r =-0.636, r =0.627, P 〈0.01）. Expression of CD8 T cell exhibited negative correlation with CHE （r =-0.389, P 〈0.01）. [Conclusions] Cellular immunity function and erythrocyte immunity function are disordered in cirrhosis patients. Expression of CD58 correlate positively with liver cell function＇s disorder. Liver cell function＇s disorder may correlate with cellular immunity function. The abnormality of CD8 on crythrocytcs may influence on T lymphocyte immunity function.

关 键 词：肝硬化 红细胞 CD58 T淋巴细胞亚群 胆碱酯酶 

分 类 号：R575.2[医药卫生—消化系统]