一氧化氮、纤维蛋白原、D-二聚体与冠心病的关系  

Study on the relationship of plasma NO,Fib and D-dimer in coronary heart disease

作　　者：孙一荣[1] 张云[1] 矫燕[1] 

机构地区：[1]山东省聊城市第二人民医院心内科,山东聊城252600

出　　处：《中国现代医学杂志》2007年第3期374-376,共3页China Journal of Modern Medicine

摘　　要：目的探讨一氧化氮(NO)、纤维蛋白原(Fib)、D-二聚体与冠心病的关系。方法检测57例急性心肌梗死、71例不稳定心绞痛患者、52例稳定心绞痛患者血浆NO、Fib、D-二聚体含量。随机选择50例健康人做对照组。采用比色法测定NO含量;血凝仪法测定Fib含量;胶体金法测定D-二聚体含量。结果冠心病患者血浆NO含量明显低于健康对照组(P<0.01),冠心病患者血浆Fib、D-二聚体含量明显高于健康对照组(P<0.01)。冠心病患者各型之间血浆NO、Fib、D-二聚体含量比较差异有显著性意义(P<0.05)。冠心病患者血浆NO含量和Fib、D-二聚体均呈负相关,(P<0.01)。结论测定NO、Fib、D-二聚体有助于冠心病患者的病情监测及预后判断。[Objective] To study the relationship of plasma NO, Fib and D-dimer in coronary heart disease. [Methods] 180 patients with coronary heart disease were randomly recruited and divided into 3 groups： the acute myocardial infarction （AMI） group; the unstable angina pectoris （UAP） group; the stable angina pectoris （SAP） group; 50 healthy persons recruited as the control group. The levels of plasma nitrogen monoxidum were determined by colorimetry, plasma fibrinogen were determined by automated coagnlometer method; D-dimer was dertermined by colloidal gold method. [Results] The levels of plasma nitrogen monoxidum decreased significantly and the levels of Fib, D-dimer increased significantly in patients of cronory heart disease compared to those in the control group （P 〈 0.01, P 〈0.01, P 〈0.01）. There were significant differences in the levels of plasma nitrogen monoxidum, fibrinogen and D-dimer among the AMI, the SAP and the UAP group （P 〈0.05）. Negative correlations were found among the levels of plasma NO and Fib, D-dimer （r =-0.884, -0.726; P 〈0.01）.

关 键 词：一氧化氮 纤维蛋白原 D-二聚体 冠心病 

分 类 号：R743.33[医药卫生—神经病学与精神病学]