戊唑醇对映体在新型纤维素键合手性固定相上的拆分  

Enantiomeric Resolution of Tebuconazole on Immobilized Cellulose Chiral Stationary Phase

作　　者：明永飞[1] 赵亮[1] 张红丽[1] 师彦平[1] 李永民[1] 

机构地区：[1]中国科学院兰州化学物理研究所甘肃省天然药物重点实验室

出　　处：《高等学校化学学报》2007年第2期258-260,共3页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金(批准号:20375045);甘肃省自然科学基金(批准号:3ZS041-A25-23);中国科学院'西部之光'(2003)项目资助

摘　　要：The chiral stationary pahse of 3,5-dimethylphenylcarbamates of cellulose chemically bonded to 3-aminopropyl silica gel at the 6-position of the glucose units was prepared.The racemates of tebuconazole were resolved on the new immobilized chiral stationary phase,and the influences of modifiers(alcohols,THF and chloroform) in the mobile phase on the resolution were investigated.The chromatographic conditions were optimized.The results show that the new immobilized chiral stationary phase exhibits a good stereoselectivity to tebuconzole.The best resolution of 1.51 of tebuconazole was obtained by using hexane/2-propanol/ THF(volume ratio 90∶5∶5) as the mobile phase on a 150 mm column.The chiral stationary pahse of 3,5-dimethylphenylcarbamates of cellulose chemically bonded to 3-aminopropyl silica gel at the 6-position of the glucose units was prepared. The racemates of tebuconazole were resolved on the new immobilized chiral stationary phase, and the influences of modifiers（ alcohols, THF and chloroform） in the mobile phase on the resolution were investigated. The chromatographic conditions were optimized. The＇ results show that the new immobilized chiral stationary phase exhibits a good stereoselectivity to tebuconzole. The best resolution of 1.51 of tebuconazole was obtained by using hexane/2-propanol/ THF （volume ratio 90： 5： 5） as the mobile phase on a 150 mm column.

关 键 词：键合 手性固定相 手性拆分 戊唑醇 

分 类 号：O657.7[理学—分析化学]