胆固醇酯转运蛋白基因TaqⅠ多态性与多廿烷醇降脂疗效的关系  

Relationship between TaqⅠgenetic polymorphism at cholesterol ester transfer protein locus and the efficacy of policosanol

作　　者：崔艳丽[1] 赵秀丽[2] 武峰[2] 郭韶洁[2] 李嘉静[2] 周辉[2] 杨凌[2] 尚军[2] 

机构地区：[1]北京市石景山医院,北京100043 [2]首都医科大学附属北京同仁医院,北京100730

出　　处：《中国新药杂志》2007年第3期240-243,共4页Chinese Journal of New Drugs

摘　　要：目的:了解胆固醇酯转运蛋白(CETP)TaqⅠ基因多态性与新型降脂药物多廿烷醇(policosanol)疗效的关系。方法:入选54例LDL-C≥3.62 mmol.L-1,或TC≥6.2 mmol.L-1汉族原发性高胆固醇血症患者,服用10mg.d-1多廿烷醇12周,于0周和12周进行血脂检查;同时进行CETP TaqI位点多态性检测(PCR-RFLP方法)。结果:CETP基因TaqI位点B1B1,B1B2,B2B2基因型频率分别是31.48%,44.44%,24.07%。0周时apoA水平在3种基因型呈B1B1<B1B2<B2B2依次增高,且HDL-C在B1B1型最低,但apoA,HDL-C在3种基因型间差异无统计学意义。多廿烷醇治疗12周后,可显著降低TC,LDL-C,apoB和LPa(P<0.05);apoA升高无统计学意义,HDL-C升高也不明显;其中B1B1,B1B2及B2B2型的HDL-C升高分别为3.19%,0.58%和0.42%,apoA升高分别为17.00%,9.64%和8.02%,但在3种基因型间差异无统计学意义。结论:多廿烷醇能显著降低原发性高胆固醇血症患者的TC,LDL-C,apoB和Lpa,但尚不能证实CETP基因TaqⅠ多态性与多廿烷醇降脂疗效有关。Objective：To explore the correlationship of genetic polymorphism at cholesterol ester transfer protein（CETP） locus to the efficacy of policosanol. Methods：54 patients with essential hypercholesteremia with LDL-C ≥3.62 mmol· L^-1 or TC ≥16.2 mmol· L ^-1 were administrated policosanol 10 mg for 12 weeks. The blood samples from the patients were collected to determine levels of serum lipid profile, including TC, TG, HDL-C, LDL-C, apoA, apoB and Lpa before and after the treatment. The polymorphism of CETP gene was analyzed by PCR-RFLP technique. Results： The genotype frequencies of B1B1, B1B2 and B2B2 at CETP-TaqI locus were 31.48% , 44.44% and 24.07% , respectively. The patients with B1 B1 genotype had lower HDL-C and apoA levels than the patients with B1 B2 and B2B2 （P 〉0.05）. Policosanol increased HDL-C and apoA levels by 3.19% vs. 17.0% , 0.58% vs. 9.64% and 0.42% vs. 8.02% in patients with B1B1, B1B2 and B2B2 （P 〉0.05） , and decreased TC,LDL- C,apoB and Lpa levels （P 〈 0.05）. The P values of the efficacy among the three genotypes showed no statistical significance （P 〉 0.05）. Conclusion ：The efficacy of policosanol was evident but necessary to have a further investigation to be correlated with the Taq Ⅰ polymorphism at CETP locus.

关 键 词：胆固醇酯转运蛋白 基因多态性 多廿烷醇 

分 类 号：R972.6[医药卫生—药品] R969.4[医药卫生—药学]