硫酸镁对脑缺血再灌注损伤的保护作用  

Protective effect of MgSO4 infusion during cerebral ischemia and reperfusion in rat

作　　者：陈岩[1] 潘银英 江基尧[2] 徐振邦[1] 梁伟民[1] 朱伟强[1] 

机构地区：[1]上海医科大学附属华山医院麻醉科,200040 [2]第二军医大学附属长征医院神经外科

出　　处：《中华麻醉学杂志》1996年第10期510-512,共3页Chinese Journal of Anesthesiology

摘　　要：将24只SD大鼠随机分为对照组(只数=7)、缺血再灌注组(只数=9)、治疗组(只数=8),参照Pulsinelli和Brierley的脑缺血动物模型,观察了硫酸镁对大鼠脑缺血再灌注后的保护作用。与对照组和缺血再灌注组相比,硫酸镁除能增加Na^+-K^+-ATP酶的活性外(P<0.01),尚能降低脑组织含水量(P<0.01)和丙二醛含量(P<0.01),且对血压无明显影响。表明硫酸镁可起到减少钙离子内流,抑制氧自由基的产生,稳定细胞膜和减轻脑水肿的作用。To evaluate the protective effect of MgSO_4 during cerebral ischemia reperfusion,twentyfour SD rats were divided randomly into control group (n=7),ischemic reperfusion group (n=9)and MgSO_4 treatment group (n=8)with Pnlsinelli and Brierley's animal ischemic reperfusion model. Compared with the control and ischemic reperfusion group,cerebral tissue contents of water and malondialdehyde reduced markedly (P<0.01), the activity of Na^+-K^+-ATPase increased significantly (P<0.01),but MAP remained unchanged during reperfusion in treatment group. These data show that MgSO_4. plays a certain role in reducing influx of calcium, inhibiting production of oxygenic free radicals,stablizing cellular membrane and ameliorating brain edema.

关 键 词：脑缺血 再灌注损伤 脑水肿 硫酸镁 

分 类 号：R743.310.5[医药卫生—神经病学与精神病学] R742.705[医药卫生—临床医学]