宫腔镜联合免疫组织化学法确诊子宫内膜癌的临床研究  

Significance of hysteroscopy and expression of PTEN,P27 in the diagnosis of endometrium cancer

作　　者：原继荣[1] 付小萌[1] 胡双九[1] 张玲[1] 肖兵[1] 杜亚丽[1] 

机构地区：[1]哈尔滨医科大学附属第二医院,黑龙江哈尔滨150086

出　　处：《中国内镜杂志》2007年第2期150-153,共4页China Journal of Endoscopy

摘　　要：目的探讨宫腔镜及抑癌基因PTEN(phosphatase and tensin homolog deleted on chromosome ten)、P27的免疫组织化学法在子宫内膜癌及癌前病变诊断中的意义。方法宫腔镜检查846例患者,免疫组织化学SP法检测其中10例正常子宫内膜,13例子宫内膜不典型增生,32例子宫内膜癌中PTEN和P27基因表达。结果宫腔镜及病理检查确诊32例子宫内膜癌(3.78%);3种组织比较,PTEN、P27阳性表达率明显降低,差异有显著性(P<0.01)。结论宫腔镜检查直观病灶,准确活检,宜于早期诊断;PTEN、P27表达异常对子宫内膜癌发生、发展及预后判定有重要意义。[Objectie] To evaluate the value of hysteroseopy in the diagnosis of endometrium cancer and atypical hyperplasia. To assay the expression rate and clinical significance of PTEN （phosphatase and tensin homolog deleted on chromosome ten）, P27 in endometrial carcinoma. [Methods] The diagnostic technique of hysteroseopy was used to examine 846 patients. Immunohistochemistry test （spmethods） was used to examine the expression of PTEN and P27 in 10 cases of normal endometrlum, 13 cases of uterus atypical hyperplasia endometrium and 32 cases of en- dometrial carcinoma. [Results] 32 endometrial carcinoma patients （3.78%） were dignosised definitely by the combined use of hysteroseopy and directed biopsies. In endometrlal carcinoma tissues, the positive expression rates of PTEN and P27 were significantly lower than that of uterus atypical hyperplasia endometrium and normal endometrium tissues （P 〈0.01）. [Conclusion] Hysteroseopy can be used to observe the endometrial foeusis and biopsies; It is benefit to early diagnosis of endometrial carcinoma. PTEN and P27 are correlated with genesis and progression of endometrial carcinoma, and important to the value of prognosis.

关 键 词：子宫内膜癌 宫腔镜 免疫组织化学法 

分 类 号：R737.33[医药卫生—肿瘤]