对乙酰氨基酚在多壁碳纳米管修饰电极上的电化学行为及其测定  

Electrochemical behavior and determination of paracetamol at multi-wall nano-carbon tube modified glassy carbon electrode

作　　者：郑艳洁[1] 陈敬华[1] 张亚锋[1] 万红艳[1] 游勇基[2] 林新华[1] 

机构地区：[1]福建医科大学药物分析系,福州350004 [2]福建省药品检验所,福州350004

出　　处：《药物分析杂志》2007年第2期204-207,共4页Chinese Journal of Pharmaceutical Analysis

基　　金：福建省教育厅重点资助项目(JA04194)

摘　　要：目的:研究对乙酰氨基酚(ACOP)在多壁碳纳米管(MWCNTs)修饰电极上的伏安行为,建立测定 ACOP 含量的电化学分析新方法。方法:采用循环伏安法研究 ACOP 在 MWCNTs 修饰电极上的电化学行为及其含量测定方法。结果:MWCNTs 修饰电极对 ACOP 有明显的电催化作用。在 pH 4.8醋酸盐缓冲液中,氧化峰电流与 ACOP 浓度在2.0×10^(-2)～10.0μmol·L^(-1)范围内呈良好的线性关系,检测限为2.0×10^(-3)μmol·L^(-1)。结论:MWCNTs 修饰电极可有效消除制剂中其他组分对 ACOP 测定的干扰,用于实际样品中 ACOP 含量的直接测定,回收率在98.1%～100.3%之间。该方法灵敏度高、检测范围宽,结果令人满意。Objective：To study the vohammetric behavior of paracetamol （ACOP） at multi - wall nano - carbon tubes （MWCNTs） modified electrode and establish a novel method for the determination of the content of ACOP. Method ：The electrochemical behavior and content determination of ACOP using MWCNTs modified electrode were studied by cyclic vohammetry. Results：The MWCNTs modified electrode shows excellent electrocatalysis characteristics for ACOP. In pH 4. 8 acetate buffer solution, the relationship between oxidation peak current and the concentration of ACOP is linear in the range of 2. 0 × 10^-2 - 10. 0 μmol·L^-1. The detection limit has been estimated as 2. 0 × 10^-3 μmol·L^-1. Conclusion：The interference of other components in the preparation can be efficiently eliminated by the MWCNTs modified electrode. And this method can be used for the determination of ACOP in real sample with satisfactory results.

关 键 词：对乙酰氨基酚(ACOP) 多壁碳纳米管(MWCNTs)修饰电极 循环伏安法 

分 类 号：R917[医药卫生—药物分析学]