石榴籽油对实验性高脂血症大鼠血脂及脂质过氧化的影响  

Adjustment Effects of Seed Oil of Punica gramatum L. on Blood-lipid and Lipid-Hyperoxidation in Hyperlipidemia Rats

作　　者：李文敏[1] 敖明章[2] 汪俊汉[3] 余龙江[2] 张永忠[2] 万军梅[2] 

机构地区：[1]湖北职业技术学院医学院,湖北孝感432100 [2]华中科技大学生命科学与技术学院,湖北武汉430074 [3]华中科技大学医院检验科,湖北武汉430074

出　　处：《食品科学》2007年第2期309-312,共4页Food Science

摘　　要：目的:研究石榴籽油对高脂血症和脂质过氧化的调节作用。方法:50只雌性Wistar大鼠按体重均衡随机分为5组:空白对照组,模型对照组,石榴籽油高、低剂量组,辛伐他汀组,除空白对照组饲喂普通饲料外,其余各组饲喂高脂饲料并进行干预实验比较。结果:12w后,血清与肝脏TC、TG、MDA、LDL-C、AI等指标,高脂模型组均显著高于空白对照组(p<0.05或p<0.01),而HDL-C/TC、SOD活力均下降(p<0.05或p<0.01);石榴籽油小剂量组血清与肝脏TC、TG、MDA、血清LDL-C、AI等指标均显著低于高脂模型组(p<0.05或p<0.01),而HDL-C/TC、SOD活力均升高(p<0.05或p<0.01)。结论:石榴籽油对大鼠的高脂血症和动脉硬化的形成有明显的抑制作用。Objective; To study the adjustment effects of seed oil of Punica gramatum L. on blood-lipid and lipid-hyperoxidation in hypedipidemia rats. Method： 50 female Wistar rats were divided randomly into 5 groups by body weight： control group, hyperlipidemia model group, seed oil of Punica gramatum L high and low dose group and simvastatin group. The rats were fed with high-lipid foodstuff except control group, so the intervention tests were carded out. Results： After twelve weeks, the contents of serum and hepar total cholesterol（TC）, tdglyceride（TG）, low-density lipoprotein cholesterol（LDL-C）, arteriosclerosis index （AI） and malondialdehyde（MDA） of hyperlipidemia model group were all higher than the control group （p 〈 0.05 or p 〈 0.01）, but high density lipoprotein ratio to total cholesterol （HDL-C/TC） and superoxide dismutase （SOD） activities were lower than the control group（p 〈 0.05 or p 〈 0.01）. The contents of serum and hepar total cholesterol（TC）, tdglyceride（TG）, low-density lipoprotein cholesterol（LDL-C）, arteriosclerosis index（AI）, malondialdehyde（MDA） in Punica gramatum L. low dose seed oil group were all lower than the hyperlipidemia model group （p 〈 0.05 or p 〈 0.01）, but the high density lipoprotein ratio total cholesterol （HDL-C/TC） and superoxide dismutase（SOD） activities were higher than the control hyperlipidemia model group （p 〈 0.05 or p 〈 0.01）. Conclusion： Seed oil of Punica gramatum L. has significant effects on controlling hyperlipidemia and atherosclerosis in rats.

关 键 词：石榴籽油 高脂血症大鼠 脂质过氧化 预防 

分 类 号：TS222.1[轻工技术与工程—粮食、油脂及植物蛋白工程]