癫痫与电压依赖性钠离子通道的分子遗传学进展  

Molecular Genetics Progression of Epilepsy and Voltage-gated Sodium Channels

作　　者：于娜[1] 蔡际群[1] 

机构地区：[1]中国医科大学药物毒理教研室,沈阳110001

出　　处：《国际遗传学杂志》2007年第1期34-38,共5页International Journal of Genetics

基　　金：国家自然科学基金（30270535）

摘　　要：癫痫是一类抽搐相关性神经系统疾病，其发病机制复杂，临床治疗困难，严重影响人类的健康。随着分子遗传学和药理学的发展，癫痫的发病机制也取得了很大的进展。大量的研究表明，电压依赖性离子通道在癫痫的发病中发挥着重要的作用。现从分子水平对电压依赖性钠离子通道与癫痫的相关性及其亚基的相互作用方面进行综述。Epilepsy is a nervous system disease related with convulsion. The pathogenesy is multifold. Clinic therapy is difficult. Human＇s health is affected seriously. With the development of molecular genetics and pharmacology, pathogenesy of epilepsy has an enormous progression. A lot of investigation indicates that voltage-gated sodium channels play a significant role. This review summarizes the dependability between voltage-gated sodium channels and epilepsy and the interaction of subunits at molecular levels.

关 键 词：癫痫 电压依赖性钠离子通道 

分 类 号：R742[医药卫生—神经病学与精神病学]