缺氧诱导因子脯氨酸羟化酶的调控与缺血缺氧性疾病  

Regulation of hypoxia-inducible factor proline hydroxylase activity and hypoxic/ischemic diseases

作　　者：聂金 戴爱国 胡瑞成 

机构地区：[1]湖南省老年医院

出　　处：《国际病理科学与临床杂志》2007年第1期53-56,共4页Journal of International Pathology and Clinical Medicine

基　　金：国家自然科学基金(30270581;30570815);中国博士后科学基金(2003033436);教育部科学技术重点项目(03091);湖南省自然科学基金(05JJ30073)~~

摘　　要：缺氧诱导因子脯氨酸羟化酶作为氧感受器,通过氧依赖性地催化缺氧诱导因子特定脯氨酸残基的羟基化反应,从而介导缺氧诱导因子的降解,在缺氧诱导因子转录活性的调控过程中具有重要作用。缺氧诱导因子在各种缺血缺氧性疾病的发生及发展过程中起重要作用,但直接抑制其转录活性十分困难,因此深入研究其特异性的脯氨酸羟化酶的活性调控可能为防治此类疾病提供新的策略。Act as the oxygen sensor, hypoxia-inducible factor （HIF） proline hydroxylases （PHDs）, oxygen-dependent catalyse hydroxylation of specific proline residues in the HIFs-alpha subunits, and mediation the degradation of HIFs, so play a central role in regulation the transcriptional activity of HIFs. Activity of PHDs is regulated by many factors. HIFs play an important role in the pathogenesis and development of various hypoxic/ischemic diseases. Because it is very difficult to repress the transcriptional activity of HIFs directly, so the deep study on the regulation of PHDs activity may propose new strategy to prevent and cure hypoxic/ischemic diseases.

关 键 词：缺氧诱导因子脯氨酸羟化酶 缺氧诱导因子 缺血 缺氧 

分 类 号：R363[医药卫生—病理学]